| http://purl.uniprot.org/citations/12200974 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12200974 | http://www.w3.org/2000/01/rdf-schema#comment | "Cell-surface proteoglycans participate in several biological functions including interactions with adhesion molecules, growth factors and a variety of other effector molecules. Accordingly, these molecules play a central role in various aspects of cell-cell and cell-matrix interactions. To investigate the expression and distribution of the cell surface proteoglycans, syndecan-1 and -2, during periodontal wound healing, immunohistochemical analyses were carried out using monoclonal antibodies against syndecan-1, or -2 core proteins. Both syndecan-1 and -2 were expressed and distributed differentially at various stages of early inflammatory cell infiltration, granulation tissue formation, and tissue remodeling in periodontal wound healing. Expression of syndecan-1 was noted in inflammatory cells within and around the fibrin clots during the earliest stages of inflammatory cells infiltration. During granulation tissue formation it was noted in fibroblast-like cells and newly formed blood vessels. Syndecan-1 was not seen in newly formed bone or cementum matrix at any of the time periods studied. Syndecan-1 expression was generally less during the late stages of wound healing but was markedly expressed in cells that were close to the repairing junctional epithelium. In contrast, syndecan-2 expression and distribution was not evident at the early stages of inflammatory cell infiltration. During the formation of granulation tissue and subsequent tissue remodeling, syndecan-2 was expressed extracellularly in the newly formed fibrils which were oriented toward the root surface. Syndecan-2 was found to be significantly expressed on cells that were close to the root surface and within the matrix of repaired cementum covering root dentin as well as at the alveolar bone edge. These findings indicate that syndecan-1 and -2 may have distinctive functions during wound healing of the periodontium. The appearance of syndecan-1 may involve both cell-cell and cell-matrix interactions, while syndecan-2 showed a predilection to associate with cell-matrix interactions during hard tissue formation."xsd:string |
| http://purl.uniprot.org/citations/12200974 | http://purl.org/dc/terms/identifier | "doi:10.1034/j.1600-0765.2002.01624.x"xsd:string |
| http://purl.uniprot.org/citations/12200974 | http://purl.uniprot.org/core/author | "Li H."xsd:string |
| http://purl.uniprot.org/citations/12200974 | http://purl.uniprot.org/core/author | "Xiao Y."xsd:string |
| http://purl.uniprot.org/citations/12200974 | http://purl.uniprot.org/core/author | "Young W.G."xsd:string |
| http://purl.uniprot.org/citations/12200974 | http://purl.uniprot.org/core/author | "Bartold P.M."xsd:string |
| http://purl.uniprot.org/citations/12200974 | http://purl.uniprot.org/core/author | "Worapamorn W."xsd:string |
| http://purl.uniprot.org/citations/12200974 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12200974 | http://purl.uniprot.org/core/name | "J Periodontal Res"xsd:string |
| http://purl.uniprot.org/citations/12200974 | http://purl.uniprot.org/core/pages | "293-299"xsd:string |
| http://purl.uniprot.org/citations/12200974 | http://purl.uniprot.org/core/title | "Differential expression and distribution of syndecan-1 and -2 in periodontal wound healing of the rat."xsd:string |
| http://purl.uniprot.org/citations/12200974 | http://purl.uniprot.org/core/volume | "37"xsd:string |
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