| http://purl.uniprot.org/citations/12202038 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12202038 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12202038 | http://www.w3.org/2000/01/rdf-schema#comment | "Using coimmunoprecipitation and tandem mass spectrometry, we identify INSIG-1 as an ER protein that binds the sterol-sensing domain of SREBP cleavage-activating protein (SCAP) and facilitates retention of the SCAP/SREBP complex in the ER. In sterol-depleted cells, SCAP escorts SREBPs from ER to Golgi for proteolytic processing, thereby allowing SREBPs to stimulate cholesterol synthesis. Sterols induce binding of SCAP to INSIG-1, as determined by blue native-PAGE, and this is correlated with the inhibition of SCAP exit from the ER. Overexpression of INSIG-1 increases the sensitivity of cells to sterol-mediated inhibition of SREBP processing. Mutant SCAP(Y298C) fails to bind INSIG-1 and is resistant to sterol-mediated inhibition of ER exit. By facilitating sterol-dependent ER retention of SCAP, INSIG-1 plays a central role in cholesterol homeostasis."xsd:string |
| http://purl.uniprot.org/citations/12202038 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0092-8674(02)00872-3"xsd:string |
| http://purl.uniprot.org/citations/12202038 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0092-8674(02)00872-3"xsd:string |
| http://purl.uniprot.org/citations/12202038 | http://purl.uniprot.org/core/author | "Aebersold R."xsd:string |
| http://purl.uniprot.org/citations/12202038 | http://purl.uniprot.org/core/author | "Aebersold R."xsd:string |
| http://purl.uniprot.org/citations/12202038 | http://purl.uniprot.org/core/author | "Gong Y."xsd:string |
| http://purl.uniprot.org/citations/12202038 | http://purl.uniprot.org/core/author | "Gong Y."xsd:string |
| http://purl.uniprot.org/citations/12202038 | http://purl.uniprot.org/core/author | "Yang T."xsd:string |
| http://purl.uniprot.org/citations/12202038 | http://purl.uniprot.org/core/author | "Yang T."xsd:string |
| http://purl.uniprot.org/citations/12202038 | http://purl.uniprot.org/core/author | "Brown M.S."xsd:string |
| http://purl.uniprot.org/citations/12202038 | http://purl.uniprot.org/core/author | "Brown M.S."xsd:string |
| http://purl.uniprot.org/citations/12202038 | http://purl.uniprot.org/core/author | "Goldstein J.L."xsd:string |
| http://purl.uniprot.org/citations/12202038 | http://purl.uniprot.org/core/author | "Goldstein J.L."xsd:string |
| http://purl.uniprot.org/citations/12202038 | http://purl.uniprot.org/core/author | "Espenshade P.J."xsd:string |
| http://purl.uniprot.org/citations/12202038 | http://purl.uniprot.org/core/author | "Espenshade P.J."xsd:string |
| http://purl.uniprot.org/citations/12202038 | http://purl.uniprot.org/core/author | "Wright M.E."xsd:string |
| http://purl.uniprot.org/citations/12202038 | http://purl.uniprot.org/core/author | "Wright M.E."xsd:string |
| http://purl.uniprot.org/citations/12202038 | http://purl.uniprot.org/core/author | "Yabe D."xsd:string |
| http://purl.uniprot.org/citations/12202038 | http://purl.uniprot.org/core/author | "Yabe D."xsd:string |
| http://purl.uniprot.org/citations/12202038 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12202038 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12202038 | http://purl.uniprot.org/core/name | "Cell"xsd:string |
| http://purl.uniprot.org/citations/12202038 | http://purl.uniprot.org/core/name | "Cell"xsd:string |