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http://purl.uniprot.org/citations/12202833http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/12202833http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/12202833http://www.w3.org/2000/01/rdf-schema#comment"The Escherichia coli catabolite activator protein (CAP) activates transcription at P(lac), P(gal), and other promoters through interactions with the RNA polymerase alpha subunit carboxyl-terminal domain (alphaCTD). We determined the crystal structure of the CAP-alphaCTD-DNA complex at a resolution of 3.1 angstroms. CAP makes direct protein-protein interactions with alphaCTD, and alphaCTD makes direct protein-DNA interactions with the DNA segment adjacent to the DNA site for CAP. There are no large-scale conformational changes in CAP and alphaCTD, and the interface between CAP and alphaCTD is small. These findings are consistent with the proposal that activation involves a simple "recruitment" mechanism."xsd:string
http://purl.uniprot.org/citations/12202833http://purl.org/dc/terms/identifier"doi:10.1126/science.1076376"xsd:string
http://purl.uniprot.org/citations/12202833http://purl.org/dc/terms/identifier"doi:10.1126/science.1076376"xsd:string
http://purl.uniprot.org/citations/12202833http://purl.uniprot.org/core/author"Liu J."xsd:string
http://purl.uniprot.org/citations/12202833http://purl.uniprot.org/core/author"Liu J."xsd:string
http://purl.uniprot.org/citations/12202833http://purl.uniprot.org/core/author"Yang H."xsd:string
http://purl.uniprot.org/citations/12202833http://purl.uniprot.org/core/author"Yang H."xsd:string
http://purl.uniprot.org/citations/12202833http://purl.uniprot.org/core/author"Lawson C.L."xsd:string
http://purl.uniprot.org/citations/12202833http://purl.uniprot.org/core/author"Lawson C.L."xsd:string
http://purl.uniprot.org/citations/12202833http://purl.uniprot.org/core/author"Ebright R.H."xsd:string
http://purl.uniprot.org/citations/12202833http://purl.uniprot.org/core/author"Ebright R.H."xsd:string
http://purl.uniprot.org/citations/12202833http://purl.uniprot.org/core/author"Berman H.M."xsd:string
http://purl.uniprot.org/citations/12202833http://purl.uniprot.org/core/author"Berman H.M."xsd:string
http://purl.uniprot.org/citations/12202833http://purl.uniprot.org/core/author"Benoff B."xsd:string
http://purl.uniprot.org/citations/12202833http://purl.uniprot.org/core/author"Benoff B."xsd:string
http://purl.uniprot.org/citations/12202833http://purl.uniprot.org/core/author"Blatter E."xsd:string
http://purl.uniprot.org/citations/12202833http://purl.uniprot.org/core/author"Blatter E."xsd:string
http://purl.uniprot.org/citations/12202833http://purl.uniprot.org/core/author"Ebright Y.W."xsd:string
http://purl.uniprot.org/citations/12202833http://purl.uniprot.org/core/author"Ebright Y.W."xsd:string
http://purl.uniprot.org/citations/12202833http://purl.uniprot.org/core/author"Parkinson G."xsd:string
http://purl.uniprot.org/citations/12202833http://purl.uniprot.org/core/author"Parkinson G."xsd:string
http://purl.uniprot.org/citations/12202833http://purl.uniprot.org/core/date"2002"xsd:gYear
http://purl.uniprot.org/citations/12202833http://purl.uniprot.org/core/date"2002"xsd:gYear