| http://purl.uniprot.org/citations/12203782 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12203782 | http://www.w3.org/2000/01/rdf-schema#comment | "Granulosa cell tumors (GCTs) of the ovary are relatively rare and account for <5% of all ovarian cancers. The molecular pathogenesis of these tumors is not well understood. We tested the hypothesis that cyclin-dependent kinase inhibitors, specifically the inhibitors of the cyclin-dependent kinase 4 (INK4) family, are targets for altered gene expression in GCTs. The status of RB1, INK4A, INK4B, INK4C, INK4D, and ARF in 13 adult and 2 juvenile ovarian GCTs was determined by reverse transcription-polymerase chain reaction of total RNA and exon-specific sequencing of genomic DNA. Tumors showing loss of INK4A expression were assayed further by exon-deletion analysis and methylation-specific PCR. None of the juvenile tumors demonstrated altered expression, but 7/12 (58%) adult GCTs lacked expression of INK4A, INK4B, or both. In one of these cases, we noted a homozygous deletion of the INK4A locus, and in the remaining tumors we found hypermethylation of the promoter region, a mechanism that can lead to gene inactivation. These data support a role for the INK4 family of CDK inhibitors in the biology of GCTs."xsd:string |
| http://purl.uniprot.org/citations/12203782 | http://purl.org/dc/terms/identifier | "doi:10.1002/gcc.10108"xsd:string |
| http://purl.uniprot.org/citations/12203782 | http://purl.uniprot.org/core/author | "Robbins S.M."xsd:string |
| http://purl.uniprot.org/citations/12203782 | http://purl.uniprot.org/core/author | "Coppes M.J."xsd:string |
| http://purl.uniprot.org/citations/12203782 | http://purl.uniprot.org/core/author | "Arcellana-Panlilio M.Y."xsd:string |
| http://purl.uniprot.org/citations/12203782 | http://purl.uniprot.org/core/author | "Magliocco A."xsd:string |
| http://purl.uniprot.org/citations/12203782 | http://purl.uniprot.org/core/author | "Egeler R.M."xsd:string |
| http://purl.uniprot.org/citations/12203782 | http://purl.uniprot.org/core/author | "Stuart G.C."xsd:string |
| http://purl.uniprot.org/citations/12203782 | http://purl.uniprot.org/core/author | "Ujack E."xsd:string |
| http://purl.uniprot.org/citations/12203782 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12203782 | http://purl.uniprot.org/core/name | "Genes Chromosomes Cancer"xsd:string |
| http://purl.uniprot.org/citations/12203782 | http://purl.uniprot.org/core/pages | "176-181"xsd:string |
| http://purl.uniprot.org/citations/12203782 | http://purl.uniprot.org/core/title | "Evidence of a role for the INK4 family of cyclin-dependent kinase inhibitors in ovarian granulosa cell tumors."xsd:string |
| http://purl.uniprot.org/citations/12203782 | http://purl.uniprot.org/core/volume | "35"xsd:string |
| http://purl.uniprot.org/citations/12203782 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12203782 |
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