| http://purl.uniprot.org/citations/12207561 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12207561 | http://www.w3.org/2000/01/rdf-schema#comment | "Classical and novel protein kinase C (PKC) isoforms are down-regulated as a result of chronic activation by certain tumour promoters and physiological stimuli; however, the mechanisms leading to down-regulation are not fully understood. In the present study, we have studied the PMA ('TPA')-induced degradation of PKCdelta in NIH 3T3 cells under culture conditions where PKCdelta displays cell-cycle-dependent down-regulation. In contrast with previous studies, a hyperphosphorylated form of this PKC isoform, promoted by calyculin A, was rapidly degraded in PMA-treated cells. Similarly, the presence of calyculin A enhanced the down-regulation of PKCdelta observed on G(1)/S-phase progression through the cell cycle. Analysis of phosphorylation-site mutants indicated that the T-loop Thr(505) phosphorylation site was critical for induced degradation."xsd:string |
| http://purl.uniprot.org/citations/12207561 | http://purl.org/dc/terms/identifier | "doi:10.1042/bj20020737"xsd:string |
| http://purl.uniprot.org/citations/12207561 | http://purl.uniprot.org/core/author | "Parker P.J."xsd:string |
| http://purl.uniprot.org/citations/12207561 | http://purl.uniprot.org/core/author | "Srivastava J."xsd:string |
| http://purl.uniprot.org/citations/12207561 | http://purl.uniprot.org/core/author | "Iturrioz X."xsd:string |
| http://purl.uniprot.org/citations/12207561 | http://purl.uniprot.org/core/author | "Procyk K.J."xsd:string |
| http://purl.uniprot.org/citations/12207561 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12207561 | http://purl.uniprot.org/core/name | "Biochem J"xsd:string |
| http://purl.uniprot.org/citations/12207561 | http://purl.uniprot.org/core/pages | "349-355"xsd:string |
| http://purl.uniprot.org/citations/12207561 | http://purl.uniprot.org/core/title | "Phosphorylation is required for PMA- and cell-cycle-induced degradation of protein kinase Cdelta."xsd:string |
| http://purl.uniprot.org/citations/12207561 | http://purl.uniprot.org/core/volume | "368"xsd:string |
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