| http://purl.uniprot.org/citations/12209604 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12209604 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12209604 | http://www.w3.org/2000/01/rdf-schema#comment | "Autologous serological screening of a cDNA expression library (SEREX) derived from childhood neuroblastoma led to the identification of 10 different antigens, including 6 novel gene products. The novel antigen 018INX was derived from a small open reading frame in a region of alpha-internexin mRNA that was previously described as 3' untranslated region. 018INX thus represents a novel type of tumor antigen. Five novel gene products were derived from NNP-1 (NNP3) and Hu genes (HuC-L, HuD3, HuDY, HuD1pro(c)). As indicated by sequence analysis, these antigens were generated by alternative splicing and/or alternative promoter usage or allelic polymorphism. mRNA expression analyses revealed different tissue restrictions of novel compared to known HuD and NNP-1 transcripts in normal and malignant tissues. The expressions patterns of distinct transcripts indicated potential clinical meanings as diagnostic and/or prognostic tissue markers. When kinetics of serum antibody titres against SEREX-defined antigens were compared to tumor load over time in our patient with neuroblastoma, we found 100-fold increases of anti-Hu and anti-018INX antibody titres preceding the clinical diagnosis of recurrent tumor growth after 2 years. When sera of pediatric patients with cancer (30) and healthy controls (30) were tested for humoral responses to SEREX-defined neuroblastoma antigens, we detected antibodies against all known antigens and NNP3 with low frequencies and titres in control sera, while anti-018INX and anti-Hu antibodies were found in cancer patients only. Our findings indicate that SEREX-defined tumor antigens might provide novel tools for understanding and treatment of this aggressive childhood malignancy."xsd:string |
| http://purl.uniprot.org/citations/12209604 | http://purl.org/dc/terms/identifier | "doi:10.1002/ijc.10550"xsd:string |
| http://purl.uniprot.org/citations/12209604 | http://purl.org/dc/terms/identifier | "doi:10.1002/ijc.10550"xsd:string |
| http://purl.uniprot.org/citations/12209604 | http://purl.uniprot.org/core/author | "Behrends U."xsd:string |
| http://purl.uniprot.org/citations/12209604 | http://purl.uniprot.org/core/author | "Behrends U."xsd:string |
| http://purl.uniprot.org/citations/12209604 | http://purl.uniprot.org/core/author | "Golbeck A."xsd:string |
| http://purl.uniprot.org/citations/12209604 | http://purl.uniprot.org/core/author | "Golbeck A."xsd:string |
| http://purl.uniprot.org/citations/12209604 | http://purl.uniprot.org/core/author | "Lechner B."xsd:string |
| http://purl.uniprot.org/citations/12209604 | http://purl.uniprot.org/core/author | "Lechner B."xsd:string |
| http://purl.uniprot.org/citations/12209604 | http://purl.uniprot.org/core/author | "Mueller-Weihrich S."xsd:string |
| http://purl.uniprot.org/citations/12209604 | http://purl.uniprot.org/core/author | "Mueller-Weihrich S."xsd:string |
| http://purl.uniprot.org/citations/12209604 | http://purl.uniprot.org/core/author | "Schmid I."xsd:string |
| http://purl.uniprot.org/citations/12209604 | http://purl.uniprot.org/core/author | "Schmid I."xsd:string |
| http://purl.uniprot.org/citations/12209604 | http://purl.uniprot.org/core/author | "Berthold F."xsd:string |
| http://purl.uniprot.org/citations/12209604 | http://purl.uniprot.org/core/author | "Berthold F."xsd:string |
| http://purl.uniprot.org/citations/12209604 | http://purl.uniprot.org/core/author | "Jandl T."xsd:string |
| http://purl.uniprot.org/citations/12209604 | http://purl.uniprot.org/core/author | "Jandl T."xsd:string |
| http://purl.uniprot.org/citations/12209604 | http://purl.uniprot.org/core/author | "Mautner J.M."xsd:string |
| http://purl.uniprot.org/citations/12209604 | http://purl.uniprot.org/core/author | "Mautner J.M."xsd:string |
| http://purl.uniprot.org/citations/12209604 | http://purl.uniprot.org/core/author | "Till H."xsd:string |
| http://purl.uniprot.org/citations/12209604 | http://purl.uniprot.org/core/author | "Till H."xsd:string |
| http://purl.uniprot.org/citations/12209604 | http://purl.uniprot.org/core/author | "Voltz R."xsd:string |
| http://purl.uniprot.org/citations/12209604 | http://purl.uniprot.org/core/author | "Voltz R."xsd:string |