| http://purl.uniprot.org/citations/12209992 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12209992 | http://www.w3.org/2000/01/rdf-schema#comment | "The priming of an appropriate anti-tumor T cell response rarely results in the rejection of established tumors. The characteristics of tumors that allow them to evade a T cell-mediated rejection are unknown for many tumors. We report on evidence that the expression of the immunosuppressive enzyme, indoleamine 2,3-dioxygenase (IDO) by mononuclear cells that invade tumors and tumor-draining lymph nodes, is 1 mechanism that may account for this observation. Lewis lung carcinoma (LLC) cells stimulated a more robust allogeneic T cell response in vitro in the presence of a competitive inhibitor of IDO, 1-methyl tryptophan. When administered in vivo this inhibitor also resulted in delayed LLC tumor growth in syngeneic mice. Our study provides evidence for a novel mechanism whereby tumors evade rejection by the immune system, and suggests the possibility that inhibiting IDO may be developed as an anti-cancer immunotherapeutic strategy."xsd:string |
| http://purl.uniprot.org/citations/12209992 | http://purl.org/dc/terms/identifier | "doi:10.1002/ijc.10645"xsd:string |
| http://purl.uniprot.org/citations/12209992 | http://purl.uniprot.org/core/author | "Jennings R."xsd:string |
| http://purl.uniprot.org/citations/12209992 | http://purl.uniprot.org/core/author | "Mellor A.L."xsd:string |
| http://purl.uniprot.org/citations/12209992 | http://purl.uniprot.org/core/author | "Munn D.H."xsd:string |
| http://purl.uniprot.org/citations/12209992 | http://purl.uniprot.org/core/author | "Antonia S.J."xsd:string |
| http://purl.uniprot.org/citations/12209992 | http://purl.uniprot.org/core/author | "Cantor A."xsd:string |
| http://purl.uniprot.org/citations/12209992 | http://purl.uniprot.org/core/author | "Friberg M."xsd:string |
| http://purl.uniprot.org/citations/12209992 | http://purl.uniprot.org/core/author | "Alsarraj M."xsd:string |
| http://purl.uniprot.org/citations/12209992 | http://purl.uniprot.org/core/author | "Dessureault S."xsd:string |
| http://purl.uniprot.org/citations/12209992 | http://purl.uniprot.org/core/author | "Extermann M."xsd:string |
| http://purl.uniprot.org/citations/12209992 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12209992 | http://purl.uniprot.org/core/name | "Int J Cancer"xsd:string |
| http://purl.uniprot.org/citations/12209992 | http://purl.uniprot.org/core/pages | "151-155"xsd:string |
| http://purl.uniprot.org/citations/12209992 | http://purl.uniprot.org/core/title | "Indoleamine 2,3-dioxygenase contributes to tumor cell evasion of T cell-mediated rejection."xsd:string |
| http://purl.uniprot.org/citations/12209992 | http://purl.uniprot.org/core/volume | "101"xsd:string |
| http://purl.uniprot.org/citations/12209992 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12209992 |
| http://purl.uniprot.org/citations/12209992 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/12209992 |
| http://purl.uniprot.org/uniprot/#_D3YXV1-mappedCitation-12209992 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12209992 |
| http://purl.uniprot.org/uniprot/#_P28776-mappedCitation-12209992 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12209992 |
| http://purl.uniprot.org/uniprot/D3YXV1 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/12209992 |
| http://purl.uniprot.org/uniprot/P28776 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/12209992 |