| http://purl.uniprot.org/citations/12213716 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12213716 | http://www.w3.org/2000/01/rdf-schema#comment | "The majority of pediatric anaplastic large cell lymphomas (ALCLs) carry the t(2;5)(p23;q35) chromosomal translocation that juxtaposes the dimerization domain of nucleophosmin with anaplastic lymphoma kinase (ALK). The nucleophosmin-ALK fusion induces constitutive, ligand-independent activation of the ALK tyrosine kinase leading to aberrant activation of cellular signaling pathways. To study the early consequences of ectopic ALK activation, a GyrB-ALK fusion was constructed that allowed regulated dimerization with the addition of coumermycin. Expression of the fusion protein caused a coumermycin-dependent increase in cellular tyrosine phosphorylation and c-Myc immunoreactivity, which was paralleled by a rise in c-myc RNA. To assess the clinical relevance of this observation, c-Myc expression was determined in pediatric ALK-positive and -negative lymphomas. Co-expression of c-Myc and ALK was seen in tumor cells in 15 of 15 (100%) ALK-positive ALCL samples, whereas no expression of either ALK or c-Myc was seen in six of six cases of ALK-negative T-cell lymphoma. C-Myc may be a downstream target of ALK signaling and its expression a defining characteristic of ALK-positive ALCLs."xsd:string |
| http://purl.uniprot.org/citations/12213716 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0002-9440(10)64248-4"xsd:string |
| http://purl.uniprot.org/citations/12213716 | http://purl.uniprot.org/core/author | "Virshup D.M."xsd:string |
| http://purl.uniprot.org/citations/12213716 | http://purl.uniprot.org/core/author | "Carroll W.L."xsd:string |
| http://purl.uniprot.org/citations/12213716 | http://purl.uniprot.org/core/author | "Perkins S.L."xsd:string |
| http://purl.uniprot.org/citations/12213716 | http://purl.uniprot.org/core/author | "Carlson M.A."xsd:string |
| http://purl.uniprot.org/citations/12213716 | http://purl.uniprot.org/core/author | "Raetz E.A."xsd:string |
| http://purl.uniprot.org/citations/12213716 | http://purl.uniprot.org/core/author | "Schooler K.P."xsd:string |
| http://purl.uniprot.org/citations/12213716 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12213716 | http://purl.uniprot.org/core/name | "Am J Pathol"xsd:string |
| http://purl.uniprot.org/citations/12213716 | http://purl.uniprot.org/core/pages | "875-883"xsd:string |
| http://purl.uniprot.org/citations/12213716 | http://purl.uniprot.org/core/title | "The nucleophosmin-anaplastic lymphoma kinase fusion protein induces c-Myc expression in pediatric anaplastic large cell lymphomas."xsd:string |
| http://purl.uniprot.org/citations/12213716 | http://purl.uniprot.org/core/volume | "161"xsd:string |
| http://purl.uniprot.org/citations/12213716 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12213716 |
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| http://purl.uniprot.org/uniprot/#_A0A0B4J1R1-mappedCitation-12213716 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12213716 |
| http://purl.uniprot.org/uniprot/#_A0A0K2YUJ3-mappedCitation-12213716 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12213716 |
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