| http://purl.uniprot.org/citations/12213839 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12213839 | http://www.w3.org/2000/01/rdf-schema#comment | "N-cadherin, a member of the Ca(2+)-dependent cell-cell adhesion molecule family, plays an essential role in skeletal muscle cell differentiation. We show that inhibition of N-cadherin-dependent adhesion impairs the upregulation of the two cyclin-dependent kinase inhibitors p21 and p27, the expression of the muscle-specific genes myogenin and troponin T, and C2C12 myoblast fusion. To determine the nature of N-cadherin-mediated signals involved in myogenesis, we investigated whether N-cadherin-dependent adhesion regulates the activity of Rac1, Cdc42Hs, and RhoA. N-cadherin-dependent adhesion decreases Rac1 and Cdc42Hs activity, and as a consequence, c-jun NH2-terminal kinase (JNK) MAPK activity but not that of the p38 MAPK pathway. On the other hand, N-cadherin-mediated adhesion increases RhoA activity and activates three skeletal muscle-specific promoters. Furthermore, RhoA activity is required for beta-catenin accumulation at cell-cell contact sites. We propose that cell-cell contacts formed via N-cadherin trigger signaling events that promote the commitment to myogenesis through the positive regulation of RhoA and negative regulation of Rac1, Cdc42Hs, and JNK activities."xsd:string |
| http://purl.uniprot.org/citations/12213839 | http://purl.org/dc/terms/identifier | "doi:10.1083/jcb.200202034"xsd:string |
| http://purl.uniprot.org/citations/12213839 | http://purl.uniprot.org/core/author | "Blangy A."xsd:string |
| http://purl.uniprot.org/citations/12213839 | http://purl.uniprot.org/core/author | "Charrasse S."xsd:string |
| http://purl.uniprot.org/citations/12213839 | http://purl.uniprot.org/core/author | "Gauthier-Rouviere C."xsd:string |
| http://purl.uniprot.org/citations/12213839 | http://purl.uniprot.org/core/author | "Meriane M."xsd:string |
| http://purl.uniprot.org/citations/12213839 | http://purl.uniprot.org/core/author | "Comunale F."xsd:string |
| http://purl.uniprot.org/citations/12213839 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12213839 | http://purl.uniprot.org/core/name | "J Cell Biol"xsd:string |
| http://purl.uniprot.org/citations/12213839 | http://purl.uniprot.org/core/pages | "953-965"xsd:string |
| http://purl.uniprot.org/citations/12213839 | http://purl.uniprot.org/core/title | "N-cadherin-dependent cell-cell contact regulates Rho GTPases and beta-catenin localization in mouse C2C12 myoblasts."xsd:string |
| http://purl.uniprot.org/citations/12213839 | http://purl.uniprot.org/core/volume | "158"xsd:string |
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