| http://purl.uniprot.org/citations/12214252 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12214252 | http://www.w3.org/2000/01/rdf-schema#comment | "Centrosome duplication is under precise control and occurs only once in a normal mammalian cell cycle. Disruption of this process causes centrosome amplification, unequal segregation of chromosomes and, ultimately, tumorigenesis. Recent studies indicate that breast cancer suppressor gene 1 (BRCA1) plays an important role in regulating centrosome duplication. BRCA1 is located in the centrosome and binds to gamma-tubulin. It interacts with a variety of proteins that regulate centrosome duplication, including BRCA2, CDK2-Cyclin A, CDK2-Cyclin E, Gadd45, p21, p53 and Rb. Furthermore, targeted disruption of murine BRCA1 results in centrosome amplification, suggesting that BRCA1 serves as a negative regulator for centrosome duplication. This review will examine these data and discuss possible relationships between BRCA1 and its interacting proteins in centrosome duplication."xsd:string |
| http://purl.uniprot.org/citations/12214252 | http://purl.org/dc/terms/identifier | "doi:10.1038/sj.onc.1205713"xsd:string |
| http://purl.uniprot.org/citations/12214252 | http://purl.uniprot.org/core/author | "Deng C.X."xsd:string |
| http://purl.uniprot.org/citations/12214252 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12214252 | http://purl.uniprot.org/core/name | "Oncogene"xsd:string |
| http://purl.uniprot.org/citations/12214252 | http://purl.uniprot.org/core/pages | "6222-6227"xsd:string |
| http://purl.uniprot.org/citations/12214252 | http://purl.uniprot.org/core/title | "Roles of BRCA1 in centrosome duplication."xsd:string |
| http://purl.uniprot.org/citations/12214252 | http://purl.uniprot.org/core/volume | "21"xsd:string |
| http://purl.uniprot.org/citations/12214252 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12214252 |
| http://purl.uniprot.org/citations/12214252 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/12214252 |
| http://purl.uniprot.org/uniprot/P38398#attribution-A08101206EA2A5D5D293F3B71E4098DC | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/12214252 |
| http://purl.uniprot.org/uniprot/Q9GKK8#attribution-A08101206EA2A5D5D293F3B71E4098DC | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/12214252 |
| http://purl.uniprot.org/uniprot/#_A0A087WP26-mappedCitation-12214252 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12214252 |
| http://purl.uniprot.org/uniprot/#_A0A087WPE1-mappedCitation-12214252 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12214252 |
| http://purl.uniprot.org/uniprot/#_A0A087WPK5-mappedCitation-12214252 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12214252 |
| http://purl.uniprot.org/uniprot/#_P48754-mappedCitation-12214252 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12214252 |
| http://purl.uniprot.org/uniprot/#_Q3UMS5-mappedCitation-12214252 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12214252 |
| http://purl.uniprot.org/uniprot/#_Q99LI1-mappedCitation-12214252 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12214252 |
| http://purl.uniprot.org/uniprot/#_Q6NV63-mappedCitation-12214252 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12214252 |
| http://purl.uniprot.org/uniprot/#_Q9Z1D2-mappedCitation-12214252 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12214252 |
| http://purl.uniprot.org/uniprot/Q6NV63 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/12214252 |
| http://purl.uniprot.org/uniprot/P48754 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/12214252 |
| http://purl.uniprot.org/uniprot/A0A087WPE1 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/12214252 |
| http://purl.uniprot.org/uniprot/Q99LI1 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/12214252 |