| http://purl.uniprot.org/citations/12215258 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12215258 | http://www.w3.org/2000/01/rdf-schema#comment | "C/EBPbeta is one of the key transcription factors responsible for the induction of a wide array of genes. Like many proto-oncogenes and transcription factors, transcription of C/EBPbeta gene can be induced by multiple extracellular signals. Using nuclear extracts from lipopolysaccharide (LPS)-stimulated mouse liver, five trans-acting factor-binding motifs, URE1 (-376 to -352), URE2 (-253 to -223), URE3 (-220 to -190), URE4 (-123 to -103), and URE5 (-72 to -45) were identified by DNAse I footprinting assays. Competition and supershift analysis of the complexes formed at the URE2 and URE4 indicated that they contain CREB/ATF and AP-1 family factors. Furthermore, recombinant ATF2 and c-Jun proteins from mammalian and bacterial cells can bind to URE2 and URE4 but not URE1. Cotransfection experiments showed that ATF2 and c-Jun activate the C/EBPbeta gene expression cooperatively through URE2 and URE4, and this activation was greatly increased under the treatment of low concentration of anisomycin. During acute phase response, the phosphorylation of c-Jun and ATF2 was found to correlate with C/EBPbeta gene expression. Taken together, our results provide the evidences that both c-Jun and ATF2 are the regulators of C/EBPbeta gene."xsd:string |
| http://purl.uniprot.org/citations/12215258 | http://purl.org/dc/terms/identifier | "doi:10.1089/104454902320308924"xsd:string |
| http://purl.uniprot.org/citations/12215258 | http://purl.uniprot.org/core/author | "Chang C.J."xsd:string |
| http://purl.uniprot.org/citations/12215258 | http://purl.uniprot.org/core/author | "Lee S.C."xsd:string |
| http://purl.uniprot.org/citations/12215258 | http://purl.uniprot.org/core/author | "Yen H.C."xsd:string |
| http://purl.uniprot.org/citations/12215258 | http://purl.uniprot.org/core/author | "Tsay Y.G."xsd:string |
| http://purl.uniprot.org/citations/12215258 | http://purl.uniprot.org/core/author | "Lin W.C."xsd:string |
| http://purl.uniprot.org/citations/12215258 | http://purl.uniprot.org/core/author | "Shen B.J."xsd:string |
| http://purl.uniprot.org/citations/12215258 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12215258 | http://purl.uniprot.org/core/name | "DNA Cell Biol"xsd:string |
| http://purl.uniprot.org/citations/12215258 | http://purl.uniprot.org/core/pages | "551-560"xsd:string |
| http://purl.uniprot.org/citations/12215258 | http://purl.uniprot.org/core/title | "Transcriptional activation of C/EBPbeta gene by c-Jun and ATF2."xsd:string |
| http://purl.uniprot.org/citations/12215258 | http://purl.uniprot.org/core/volume | "21"xsd:string |
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