| http://purl.uniprot.org/citations/12218114 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12218114 | http://www.w3.org/2000/01/rdf-schema#comment | "The role of TCR signals triggered by recognition of self MHCs in maintaining the survival of naive peripheral T cells remains controversial. Here we examine the role of the Src family kinases, p56(lck) (Lck) and p59(fyn) (Fyn), in the survival of naive T cells. We show that long term survival requires a combination of signals transduced by Src family kinases and signals through the IL-7R. In the absence of either one, naive T cells die slowly, but if both signals are removed, cell loss is greatly accelerated. The TCR signal can be mediated by either Fyn or Lck at wild-type levels of expression, but not by Lck alone if expressed suboptimally. The disappearance of T cells in the absence of Fyn and Lck was associated with a complete loss of TCRzeta-chain phosphorylation and down-regulation of CD5, both of which are also MHC contact dependent, indicating that the Src family kinases are critical for transducing a TCR-MHC survival signal."xsd:string |
| http://purl.uniprot.org/citations/12218114 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.169.6.2997"xsd:string |
| http://purl.uniprot.org/citations/12218114 | http://purl.uniprot.org/core/author | "Zamoyska R."xsd:string |
| http://purl.uniprot.org/citations/12218114 | http://purl.uniprot.org/core/author | "Seddon B."xsd:string |
| http://purl.uniprot.org/citations/12218114 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12218114 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/12218114 | http://purl.uniprot.org/core/pages | "2997-3005"xsd:string |
| http://purl.uniprot.org/citations/12218114 | http://purl.uniprot.org/core/title | "TCR signals mediated by Src family kinases are essential for the survival of naive T cells."xsd:string |
| http://purl.uniprot.org/citations/12218114 | http://purl.uniprot.org/core/volume | "169"xsd:string |
| http://purl.uniprot.org/citations/12218114 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12218114 |
| http://purl.uniprot.org/citations/12218114 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/12218114 |
| http://purl.uniprot.org/uniprot/#_D3YVZ0-mappedCitation-12218114 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12218114 |
| http://purl.uniprot.org/uniprot/#_D3YZ57-mappedCitation-12218114 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12218114 |
| http://purl.uniprot.org/uniprot/#_E9Q696-mappedCitation-12218114 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12218114 |
| http://purl.uniprot.org/uniprot/#_B2KG65-mappedCitation-12218114 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12218114 |
| http://purl.uniprot.org/uniprot/#_D3YZA2-mappedCitation-12218114 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12218114 |
| http://purl.uniprot.org/uniprot/#_P06240-mappedCitation-12218114 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12218114 |
| http://purl.uniprot.org/uniprot/#_P39688-mappedCitation-12218114 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12218114 |
| http://purl.uniprot.org/uniprot/#_Q3TLX4-mappedCitation-12218114 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12218114 |
| http://purl.uniprot.org/uniprot/D3YZ57 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/12218114 |
| http://purl.uniprot.org/uniprot/P06240 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/12218114 |
| http://purl.uniprot.org/uniprot/B2KG65 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/12218114 |
| http://purl.uniprot.org/uniprot/P39688 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/12218114 |
| http://purl.uniprot.org/uniprot/Q3TLX4 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/12218114 |