| http://purl.uniprot.org/citations/12220502 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12220502 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12220502 | http://www.w3.org/2000/01/rdf-schema#comment | "Extracellular signal regulated kinase1/2 (ERK1/2), an important factor in signal transduction, controls cell growth, differentiation, and death. To elucidate the details of the mechanism of ERK1/2 signaling in human cells, we isolated Nef-associated factor 1 alpha (Naf1 alpha) by a yeast two-hybrid system, which bound to human ERK2. The binding was confirmed by a pull-down assay in vitro and immunoprecipitation in vivo. Upon EGF treatment, Naf1 alpha was phosphorylated by the EGF/MEK/ERK2 signal transduction pathway. To identify the role of Naf1 alpha in the ERK2 signaling, Naf1 alpha-expressing Saos-2 cells were analyzed for ERK2 nuclear translocation and activation of its downstream target. Overexpression of Naf1 alpha suppressed ERK2 entering into the nucleus and inhibited the ERK2-dependent Elk1-driven luciferase transcription, suggesting Naf1 alpha to be an attenuator of activated ERK2 signaling."xsd:string |
| http://purl.uniprot.org/citations/12220502 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0006-291x(02)02086-7"xsd:string |
| http://purl.uniprot.org/citations/12220502 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0006-291x(02)02086-7"xsd:string |
| http://purl.uniprot.org/citations/12220502 | http://purl.uniprot.org/core/author | "Huang L."xsd:string |
| http://purl.uniprot.org/citations/12220502 | http://purl.uniprot.org/core/author | "Huang L."xsd:string |
| http://purl.uniprot.org/citations/12220502 | http://purl.uniprot.org/core/author | "Gao C."xsd:string |
| http://purl.uniprot.org/citations/12220502 | http://purl.uniprot.org/core/author | "Gao C."xsd:string |
| http://purl.uniprot.org/citations/12220502 | http://purl.uniprot.org/core/author | "Enomoto S."xsd:string |
| http://purl.uniprot.org/citations/12220502 | http://purl.uniprot.org/core/author | "Enomoto S."xsd:string |
| http://purl.uniprot.org/citations/12220502 | http://purl.uniprot.org/core/author | "Hashimoto S."xsd:string |
| http://purl.uniprot.org/citations/12220502 | http://purl.uniprot.org/core/author | "Hashimoto S."xsd:string |
| http://purl.uniprot.org/citations/12220502 | http://purl.uniprot.org/core/author | "Nakajima T."xsd:string |
| http://purl.uniprot.org/citations/12220502 | http://purl.uniprot.org/core/author | "Nakajima T."xsd:string |
| http://purl.uniprot.org/citations/12220502 | http://purl.uniprot.org/core/author | "Zhang S."xsd:string |
| http://purl.uniprot.org/citations/12220502 | http://purl.uniprot.org/core/author | "Zhang S."xsd:string |
| http://purl.uniprot.org/citations/12220502 | http://purl.uniprot.org/core/author | "Yamamoto N."xsd:string |
| http://purl.uniprot.org/citations/12220502 | http://purl.uniprot.org/core/author | "Yamamoto N."xsd:string |
| http://purl.uniprot.org/citations/12220502 | http://purl.uniprot.org/core/author | "Miura O."xsd:string |
| http://purl.uniprot.org/citations/12220502 | http://purl.uniprot.org/core/author | "Miura O."xsd:string |
| http://purl.uniprot.org/citations/12220502 | http://purl.uniprot.org/core/author | "Fukushi M."xsd:string |
| http://purl.uniprot.org/citations/12220502 | http://purl.uniprot.org/core/author | "Fukushi M."xsd:string |
| http://purl.uniprot.org/citations/12220502 | http://purl.uniprot.org/core/author | "Tsuchida N."xsd:string |
| http://purl.uniprot.org/citations/12220502 | http://purl.uniprot.org/core/author | "Tsuchida N."xsd:string |