| http://purl.uniprot.org/citations/12220507 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12220507 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12220507 | http://www.w3.org/2000/01/rdf-schema#comment | "Interleukin-1 receptor-associated kinases (IRAKs) are pivotal signaling elements of the Toll/IL-1 receptor (TIL) family, which play a role in innate immune responses by coordinating host defence mechanisms. Presently four different forms of human IRAK molecules are cloned (hu-IRAK-1, hu-IRAK-2, hu-IRAK-M, and hu-IRAK-4). In the murine system, only three genes have been identified so far, mouse Pelle-Like Kinase (mPLK), which corresponds to human IRAK-1, mu-IRAK-M, and mu-IRAK-4. Here we report the molecular cloning and characterization of murine IRAK-2 (mu-IRAK-2), a mouse homolog to human IRAK-2 (hu-IRAK-2). Murine and human IRAK-2 molecules show 67% sequence identity, they are ubiquitiously expressed, and both practically lack autophoshorylation kinase activity. The murine molecule reveals two remarkable differences to its human counterpart: it shows a C-terminal extension and it has no stimulatory effect on IL-1 induced NF-kappa B activation when compared to hu-IRAK-2, suggesting subtle functional differences in signaling by IRAK-2 in human and mouse cells."xsd:string |
| http://purl.uniprot.org/citations/12220507 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0006-291x(02)02130-7"xsd:string |
| http://purl.uniprot.org/citations/12220507 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0006-291x(02)02130-7"xsd:string |
| http://purl.uniprot.org/citations/12220507 | http://purl.uniprot.org/core/author | "Martin M.U."xsd:string |
| http://purl.uniprot.org/citations/12220507 | http://purl.uniprot.org/core/author | "Martin M.U."xsd:string |
| http://purl.uniprot.org/citations/12220507 | http://purl.uniprot.org/core/author | "Rosati O."xsd:string |
| http://purl.uniprot.org/citations/12220507 | http://purl.uniprot.org/core/author | "Rosati O."xsd:string |
| http://purl.uniprot.org/citations/12220507 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12220507 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12220507 | http://purl.uniprot.org/core/name | "Biochem. Biophys. Res. Commun."xsd:string |
| http://purl.uniprot.org/citations/12220507 | http://purl.uniprot.org/core/name | "Biochem. Biophys. Res. Commun."xsd:string |
| http://purl.uniprot.org/citations/12220507 | http://purl.uniprot.org/core/pages | "52-58"xsd:string |
| http://purl.uniprot.org/citations/12220507 | http://purl.uniprot.org/core/pages | "52-58"xsd:string |
| http://purl.uniprot.org/citations/12220507 | http://purl.uniprot.org/core/title | "Identification and characterization of murine IRAK-2."xsd:string |
| http://purl.uniprot.org/citations/12220507 | http://purl.uniprot.org/core/title | "Identification and characterization of murine IRAK-2."xsd:string |
| http://purl.uniprot.org/citations/12220507 | http://purl.uniprot.org/core/volume | "297"xsd:string |
| http://purl.uniprot.org/citations/12220507 | http://purl.uniprot.org/core/volume | "297"xsd:string |
| http://purl.uniprot.org/citations/12220507 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12220507 |
| http://purl.uniprot.org/citations/12220507 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12220507 |
| http://purl.uniprot.org/citations/12220507 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/12220507 |
| http://purl.uniprot.org/citations/12220507 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/12220507 |
| http://purl.uniprot.org/uniprot/Q8CFA1 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/12220507 |
| http://purl.uniprot.org/uniprot/Q8CFA1#attribution-1B623F9FB83F45D9C77E9B80A47C2DDB | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/12220507 |