| http://purl.uniprot.org/citations/12223487 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12223487 | http://www.w3.org/2000/01/rdf-schema#comment | "Previous studies have shown that nuclear levels of glycogen synthase kinase-3 (GSK-3) are dynamically regulated and may affect access of GSK-3 to its substrates. In this study we show that the GSK-3-binding protein Frat/GBP regulates the nuclear export of GSK-3. We show that Frat/GBP contains a nuclear export sequence that promotes its own nuclear export and that of associated GSK-3. Treating cells with leptomycin B increased nuclear levels of endogenous GSK-3 suggesting that an endogenous process targets GSK-3 for nuclear export. To investigate this further, we used two approaches to disrupt the interaction between GSK-3 and endogenous Frat. First we isolated mutants of GSK-3 that selectively interfered with Frat binding and found that these mutants were poorly exported. Second we expressed a peptide that competes with Frat for GSK-3 binding and found that it caused endogenous GSK-3 to accumulate in the nucleus. Together these data suggest that Frat may be the endogenous factor that targets GSK-3 for nuclear export. The dynamic expression patterns of Frat mRNAs together with the role of Frat in mediating GSK-3 nuclear export have important implications for the control of the substrate access of GSK-3 in several signaling pathways."xsd:string |
| http://purl.uniprot.org/citations/12223487 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m207265200"xsd:string |
| http://purl.uniprot.org/citations/12223487 | http://purl.uniprot.org/core/author | "Franca-Koh J."xsd:string |
| http://purl.uniprot.org/citations/12223487 | http://purl.uniprot.org/core/author | "Dale T.C."xsd:string |
| http://purl.uniprot.org/citations/12223487 | http://purl.uniprot.org/core/author | "Fraser E."xsd:string |
| http://purl.uniprot.org/citations/12223487 | http://purl.uniprot.org/core/author | "Yeo M."xsd:string |
| http://purl.uniprot.org/citations/12223487 | http://purl.uniprot.org/core/author | "Young N."xsd:string |
| http://purl.uniprot.org/citations/12223487 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12223487 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/12223487 | http://purl.uniprot.org/core/pages | "43844-43848"xsd:string |
| http://purl.uniprot.org/citations/12223487 | http://purl.uniprot.org/core/title | "The regulation of glycogen synthase kinase-3 nuclear export by Frat/GBP."xsd:string |
| http://purl.uniprot.org/citations/12223487 | http://purl.uniprot.org/core/volume | "277"xsd:string |
| http://purl.uniprot.org/citations/12223487 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12223487 |
| http://purl.uniprot.org/citations/12223487 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/12223487 |
| http://purl.uniprot.org/uniprot/Q92837#attribution-DF6D81D20FA5D88D040702C801366E09 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/12223487 |
| http://purl.uniprot.org/uniprot/P49841#attribution-DF6D81D20FA5D88D040702C801366E09 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/12223487 |
| http://purl.uniprot.org/uniprot/#_A4V3W1-mappedCitation-12223487 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12223487 |
| http://purl.uniprot.org/uniprot/#_A4V3W2-mappedCitation-12223487 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12223487 |
| http://purl.uniprot.org/uniprot/#_C0PUX5-mappedCitation-12223487 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12223487 |
| http://purl.uniprot.org/uniprot/#_A8JUV9-mappedCitation-12223487 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12223487 |
| http://purl.uniprot.org/uniprot/#_B2RU64-mappedCitation-12223487 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12223487 |
| http://purl.uniprot.org/uniprot/#_P70339-mappedCitation-12223487 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12223487 |
| http://purl.uniprot.org/uniprot/#_E9QAQ5-mappedCitation-12223487 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12223487 |
| http://purl.uniprot.org/uniprot/#_M9PGC4-mappedCitation-12223487 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12223487 |