| http://purl.uniprot.org/citations/12223513 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12223513 | http://www.w3.org/2000/01/rdf-schema#comment | "Cysteine-rich secretory protein 3 (CRISP-3; also known as SGP28) was originally discovered in human neutrophilic granulocytes. We have recently developed a sensitive sandwich enzyme-linked immunosorbent assay for CRISP-3 and demonstrated the presence of CRISP-3 in exocrine secretions. To investigate the subcellular localization and mobilization of CRISP-3 in human neutrophils, we performed subcellular fractionation of resting and activated neutrophils on three-layer Percoll density gradients, release-studies of granule proteins in response to different secretagogues, and double-labeling immunogold electron microscopy. CRISP-3 was found to be localized in a subset of granules with overlapping characteristics of specific and gelatinase granules and mobilized accordingly, thus confirming the hypothesis that peroxidase-negative granules exist as a continuum from specific to gelatinase granules regarding protein content and mobilization. CRISP-3 was found to be a matrix protein, which is stored in granules as glycosylated and as unglycosylated protein. The subcellular distribution of the two forms of CRISP-3 was identical. In addition, CRISP-3 was found as a granule protein in eosinophilic granulocytes. The presence of CRISP-3 in peroxidase-negative granules of neutrophils, in granules of eosinophils, and in exocrine secretions indicates a role in the innate host defense."xsd:string |
| http://purl.uniprot.org/citations/12223513 | http://purl.uniprot.org/core/author | "Borregaard N."xsd:string |
| http://purl.uniprot.org/citations/12223513 | http://purl.uniprot.org/core/author | "Kjeldsen L."xsd:string |
| http://purl.uniprot.org/citations/12223513 | http://purl.uniprot.org/core/author | "Sorensen O.E."xsd:string |
| http://purl.uniprot.org/citations/12223513 | http://purl.uniprot.org/core/author | "Udby L."xsd:string |
| http://purl.uniprot.org/citations/12223513 | http://purl.uniprot.org/core/author | "Calafat J."xsd:string |
| http://purl.uniprot.org/citations/12223513 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12223513 | http://purl.uniprot.org/core/name | "J Leukoc Biol"xsd:string |
| http://purl.uniprot.org/citations/12223513 | http://purl.uniprot.org/core/pages | "462-469"xsd:string |
| http://purl.uniprot.org/citations/12223513 | http://purl.uniprot.org/core/title | "Identification of human cysteine-rich secretory protein 3 (CRISP-3) as a matrix protein in a subset of peroxidase-negative granules of neutrophils and in the granules of eosinophils."xsd:string |
| http://purl.uniprot.org/citations/12223513 | http://purl.uniprot.org/core/volume | "72"xsd:string |
| http://purl.uniprot.org/citations/12223513 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12223513 |
| http://purl.uniprot.org/citations/12223513 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/12223513 |
| http://purl.uniprot.org/uniprot/P54108#attribution-26B39C014B5409BD9514429817C60EBA | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/12223513 |
| http://purl.uniprot.org/uniprot/P54108#attribution-BB626C8960E3A1A54F89BB10F86E8961 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/12223513 |
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| http://purl.uniprot.org/uniprot/P54108 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/12223513 |
| http://purl.uniprot.org/uniprot/B4E1S8 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/12223513 |