| http://purl.uniprot.org/citations/12225880 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12225880 | http://www.w3.org/2000/01/rdf-schema#comment | "Cerebral ischemia is caused by a reduced blood supply to neurons, and vulnerability to neurodegeneration varies considerably among neuronal types. In hippocampus, neurons in the CA1 region are more susceptible to ischemia-induced neuronal death than neurons in the CA3 region, and in response to transient forebrain ischemia a family of calcium-dependent receptors for alpha-latrotoxin is differentially expressed in the two regions. Here, we report that an ischemic insult up-regulated a family of calcium-independent receptors for alpha-latrotoxin (CIRL) mRNAs in CA1 neurons and down-regulated their mRNAs in CA3 neurons. Furthermore, antisense oligonucleotides complementary to CIRL-1 mRNA or CIRL-3 mRNA suppressed neuronal death associated with hypoxia in hippocampal and cortical cell cultures. The observed region-specific CIRL mRNA expression in hippocampus and an in vitro rescue experiment by antisense oligonucleotides against CIRL mRNAs suggest a functional importance of CIRL in neurodegeneration."xsd:string |
| http://purl.uniprot.org/citations/12225880 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0169-328x(02)00386-8"xsd:string |
| http://purl.uniprot.org/citations/12225880 | http://purl.uniprot.org/core/author | "Ruan Y."xsd:string |
| http://purl.uniprot.org/citations/12225880 | http://purl.uniprot.org/core/author | "Yokota H."xsd:string |
| http://purl.uniprot.org/citations/12225880 | http://purl.uniprot.org/core/author | "Xu Z.C."xsd:string |
| http://purl.uniprot.org/citations/12225880 | http://purl.uniprot.org/core/author | "Bin Sun H."xsd:string |
| http://purl.uniprot.org/citations/12225880 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12225880 | http://purl.uniprot.org/core/name | "Brain Res Mol Brain Res"xsd:string |
| http://purl.uniprot.org/citations/12225880 | http://purl.uniprot.org/core/pages | "246-249"xsd:string |
| http://purl.uniprot.org/citations/12225880 | http://purl.uniprot.org/core/title | "Involvement of the calcium-independent receptor for alpha-latrotoxin in brain ischemia."xsd:string |
| http://purl.uniprot.org/citations/12225880 | http://purl.uniprot.org/core/volume | "104"xsd:string |
| http://purl.uniprot.org/citations/12225880 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12225880 |
| http://purl.uniprot.org/citations/12225880 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/12225880 |
| http://purl.uniprot.org/uniprot/#_D3ZH59-mappedCitation-12225880 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12225880 |
| http://purl.uniprot.org/uniprot/#_D4A144-mappedCitation-12225880 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12225880 |
| http://purl.uniprot.org/uniprot/#_D4AAL4-mappedCitation-12225880 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12225880 |
| http://purl.uniprot.org/uniprot/#_A0A8I5ZV15-mappedCitation-12225880 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12225880 |
| http://purl.uniprot.org/uniprot/#_A0A8I5ZWD6-mappedCitation-12225880 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12225880 |
| http://purl.uniprot.org/uniprot/#_A0A8I6A141-mappedCitation-12225880 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12225880 |
| http://purl.uniprot.org/uniprot/#_A0A8I6A3I4-mappedCitation-12225880 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12225880 |
| http://purl.uniprot.org/uniprot/#_A0A8I6G3M0-mappedCitation-12225880 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12225880 |
| http://purl.uniprot.org/uniprot/#_A0A8I6GLK1-mappedCitation-12225880 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12225880 |
| http://purl.uniprot.org/uniprot/#_A0A8L2QLY5-mappedCitation-12225880 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12225880 |
| http://purl.uniprot.org/uniprot/#_A0A8I5XV01-mappedCitation-12225880 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12225880 |