| http://purl.uniprot.org/citations/12228722 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12228722 | http://www.w3.org/2000/01/rdf-schema#comment | "The mechanism by which disruption of reading frame can influence pre-messenger RNA (pre-mRNA) processing is poorly understood. We assessed the role of factors essential for nonsense-mediated mRNA decay (NMD) in nonsense-mediated altered splicing (NAS) with the use of RNA interference (RNAi) in mammalian cells. Inhibition of rent1/hUpf1 expression abrogated both NMD and NAS of nonsense T cell receptor beta transcripts. In contrast, inhibition of rent2/hUpf2 expression did not disrupt NAS despite achieving comparable stabilization of nonsense transcripts. We also demonstrate that NAS and NMD are genetically separable functions of rent1/hUpf1. Additionally, rent1/hUpf1 enters the nucleus where it may directly influence early events in mRNA biogenesis. This provides compelling evidence that NAS relies on a component of the nonsense surveillance machinery but is not an indirect consequence of NMD."xsd:string |
| http://purl.uniprot.org/citations/12228722 | http://purl.org/dc/terms/identifier | "doi:10.1126/science.1074428"xsd:string |
| http://purl.uniprot.org/citations/12228722 | http://purl.uniprot.org/core/author | "Mendell J.T."xsd:string |
| http://purl.uniprot.org/citations/12228722 | http://purl.uniprot.org/core/author | "Dietz H.C."xsd:string |
| http://purl.uniprot.org/citations/12228722 | http://purl.uniprot.org/core/author | "ap Rhys C.M."xsd:string |
| http://purl.uniprot.org/citations/12228722 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12228722 | http://purl.uniprot.org/core/name | "Science"xsd:string |
| http://purl.uniprot.org/citations/12228722 | http://purl.uniprot.org/core/pages | "419-422"xsd:string |
| http://purl.uniprot.org/citations/12228722 | http://purl.uniprot.org/core/title | "Separable roles for rent1/hUpf1 in altered splicing and decay of nonsense transcripts."xsd:string |
| http://purl.uniprot.org/citations/12228722 | http://purl.uniprot.org/core/volume | "298"xsd:string |
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