| http://purl.uniprot.org/citations/12234921 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12234921 | http://www.w3.org/2000/01/rdf-schema#comment | "The Rac/Rho-specific guanine nucleotide exchange factor, Vav-1, is a key component of the T-cell antigen receptor (TCR)-linked signaling machinery. Here we have used somatic cell gene-targeting technology to generate a Vav-1-deficient Jurkat T-cell line. The J.Vav1 cell line exhibits dramatic defects in TCR-dependent interleukin (IL)-2 promoter activation, accompanied by significant reductions in the activities of the NFAT(IL-2), NFkappaB, AP-1 and REAP transcription factors that bind to the IL-2 promoter region. In contrast, loss of Vav-1 had variable effects on early TCR-stimulated signaling events. J.Vav1 cells display a selective defect in sustained Ca(2+) signaling during TCR stimulation, and complementation of this abnormality by exogenously introduced Vav-1 is dependent on the Vav-1 calponin homology domain. While JNK activation was severely impaired, the stimulation of Ras, ERK and protein kinase C-theta activities, as well as the mobilization of lipid rafts, appeared normal in the J.Vav1 cells. Finally, evidence is presented to suggest that the alternative Vav family members, Vav-2 and Vav-3, are activated during TCR ligation, and partially compensate for the loss of Vav-1 in Jurkat T cells."xsd:string |
| http://purl.uniprot.org/citations/12234921 | http://purl.org/dc/terms/identifier | "doi:10.1093/emboj/cdf499"xsd:string |
| http://purl.uniprot.org/citations/12234921 | http://purl.uniprot.org/core/author | "Cao Y."xsd:string |
| http://purl.uniprot.org/citations/12234921 | http://purl.uniprot.org/core/author | "Billadeau D.D."xsd:string |
| http://purl.uniprot.org/citations/12234921 | http://purl.uniprot.org/core/author | "Abraham R.T."xsd:string |
| http://purl.uniprot.org/citations/12234921 | http://purl.uniprot.org/core/author | "Altman A."xsd:string |
| http://purl.uniprot.org/citations/12234921 | http://purl.uniprot.org/core/author | "Janssen E.M."xsd:string |
| http://purl.uniprot.org/citations/12234921 | http://purl.uniprot.org/core/author | "Duncan A.W."xsd:string |
| http://purl.uniprot.org/citations/12234921 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12234921 | http://purl.uniprot.org/core/name | "EMBO J"xsd:string |
| http://purl.uniprot.org/citations/12234921 | http://purl.uniprot.org/core/pages | "4809-4819"xsd:string |
| http://purl.uniprot.org/citations/12234921 | http://purl.uniprot.org/core/title | "Pleiotropic defects in TCR signaling in a Vav-1-null Jurkat T-cell line."xsd:string |
| http://purl.uniprot.org/citations/12234921 | http://purl.uniprot.org/core/volume | "21"xsd:string |
| http://purl.uniprot.org/citations/12234921 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12234921 |
| http://purl.uniprot.org/citations/12234921 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/12234921 |
| http://purl.uniprot.org/uniprot/#_A0A0A0MR07-mappedCitation-12234921 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12234921 |
| http://purl.uniprot.org/uniprot/#_A0A2X0SZ57-mappedCitation-12234921 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12234921 |
| http://purl.uniprot.org/uniprot/#_B2R8B5-mappedCitation-12234921 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12234921 |
| http://purl.uniprot.org/uniprot/#_L0R6S8-mappedCitation-12234921 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12234921 |
| http://purl.uniprot.org/uniprot/#_P15498-mappedCitation-12234921 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12234921 |
| http://purl.uniprot.org/uniprot/#_Q96D37-mappedCitation-12234921 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12234921 |
| http://purl.uniprot.org/uniprot/P15498 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/12234921 |
| http://purl.uniprot.org/uniprot/B2R8B5 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/12234921 |
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