| http://purl.uniprot.org/citations/12235238 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12235238 | http://www.w3.org/2000/01/rdf-schema#comment | "Muscarinic acetylcholine receptors (M(1)-M(5)) regulate many key functions in the central and peripheral nervous system. Due to the lack of receptor subtype-selective ligands, however, the physiological roles of individual muscarinic receptor subtypes remain to be determined. In this study, we examined the effects of the muscarinic M(2)/M(4) receptor-preferring agonist [5R-(exo)]-6-[4-butylthio-1,2,5-thiadiazol-3-yl]-1-azabicyclo-[3.2.1]-octane (BuTAC) on serum corticosterone levels in M(2) and M(4) receptor single knockout (KO) and M(2,4) receptor double KO mice. Responses were compared with those obtained with the corresponding wild-type (WT) mice. BuTAC (0.03-0.3 mg/kg s.c.) dose dependently and significantly increased serum corticosterone concentrations in WT mice to 5-fold or greater levels compared with vehicle controls. In muscarinic M(2) and M(2,4) KO mice, however, BuTAC had no significant effect on corticosterone concentrations at doses of 0.1, 0.3, and 1 mg/kg s.c. In both WT and muscarinic M(4) KO mice increases in serum corticosterone concentrations induced by BuTAC (0.1 and 0.3 mg/kg) were not significantly different and were blocked by scopolamine. In summary, the muscarinic M(2,4)-preferring agonist BuTAC had no effect on corticosterone levels in mice lacking functional muscarinic M(2) receptors. These data suggest that the muscarinic M(2) receptor subtype mediates muscarinic agonist-induced activation of the hypothalamic-pituitary-adrenocortical axis in mice."xsd:string |
| http://purl.uniprot.org/citations/12235238 | http://purl.org/dc/terms/identifier | "doi:10.1124/jpet.102.036020"xsd:string |
| http://purl.uniprot.org/citations/12235238 | http://purl.uniprot.org/core/author | "Felder C.C."xsd:string |
| http://purl.uniprot.org/citations/12235238 | http://purl.uniprot.org/core/author | "Wess J."xsd:string |
| http://purl.uniprot.org/citations/12235238 | http://purl.uniprot.org/core/author | "Evans D.C."xsd:string |
| http://purl.uniprot.org/citations/12235238 | http://purl.uniprot.org/core/author | "Bymaster F.P."xsd:string |
| http://purl.uniprot.org/citations/12235238 | http://purl.uniprot.org/core/author | "Hemrick-Luecke S.K."xsd:string |
| http://purl.uniprot.org/citations/12235238 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12235238 | http://purl.uniprot.org/core/name | "J Pharmacol Exp Ther"xsd:string |
| http://purl.uniprot.org/citations/12235238 | http://purl.uniprot.org/core/pages | "99-103"xsd:string |
| http://purl.uniprot.org/citations/12235238 | http://purl.uniprot.org/core/title | "Muscarinic agonist-mediated increases in serum corticosterone levels are abolished in m(2) muscarinic acetylcholine receptor knockout mice."xsd:string |
| http://purl.uniprot.org/citations/12235238 | http://purl.uniprot.org/core/volume | "303"xsd:string |
| http://purl.uniprot.org/citations/12235238 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12235238 |
| http://purl.uniprot.org/citations/12235238 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/12235238 |
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| http://purl.uniprot.org/uniprot/#_P32211-mappedCitation-12235238 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12235238 |
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