| http://purl.uniprot.org/citations/12236595 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12236595 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12236595 | http://www.w3.org/2000/01/rdf-schema#comment | "Genes at two unlinked loci (Tox1A and Tox1B) are required for production of the polyketide T-toxin by Cochliobolus heterostrophus race T, a pathogenic fungus that requires T-toxin for high virulence to maize with T-cytoplasm. Previous work indicated that Tox1A encodes a polyketide synthase (PKS1) required for T-toxin biosynthesis and for high virulence. To identify genes at Tox1B, a wild-type race T cDNA library was screened for genes missing in the genome of a Tox1B deletion mutant. The library was probed, first with a 415-kb NotI restriction fragment from the genome of the Tox1B mutant, then with the corresponding 560-kb fragment from the genome of wild type. Two genes, DEC1 (similar to acetoacetate decarboxylase-encoding genes) and RED1 (similar to genes encoding members of the medium-chain dehydrogenase/reductase superfamily), were recovered. Targeted disruption of DEC1 drastically reduced both T-toxin production and virulence of race T to T-cytoplasm maize, whereas specific inactivation of RED1 had no apparent effect on T-toxin production (as determined by bioassay) or on virulence. DEC1 and RED1 map within 1.5 kb of each other on Tox1B chromosome 6;12 and are unique to the genome of race T, an observation consistent with the hypothesis that these genes were acquired by C. heterostrophus via a horizontal transfer event."xsd:string |
| http://purl.uniprot.org/citations/12236595 | http://purl.org/dc/terms/identifier | "doi:10.1094/mpmi.2002.15.9.883"xsd:string |
| http://purl.uniprot.org/citations/12236595 | http://purl.org/dc/terms/identifier | "doi:10.1094/mpmi.2002.15.9.883"xsd:string |
| http://purl.uniprot.org/citations/12236595 | http://purl.uniprot.org/core/author | "Turgeon B.G."xsd:string |
| http://purl.uniprot.org/citations/12236595 | http://purl.uniprot.org/core/author | "Turgeon B.G."xsd:string |
| http://purl.uniprot.org/citations/12236595 | http://purl.uniprot.org/core/author | "Yoder O.C."xsd:string |
| http://purl.uniprot.org/citations/12236595 | http://purl.uniprot.org/core/author | "Yoder O.C."xsd:string |
| http://purl.uniprot.org/citations/12236595 | http://purl.uniprot.org/core/author | "Asvarak T."xsd:string |
| http://purl.uniprot.org/citations/12236595 | http://purl.uniprot.org/core/author | "Asvarak T."xsd:string |
| http://purl.uniprot.org/citations/12236595 | http://purl.uniprot.org/core/author | "Lu S.-W."xsd:string |
| http://purl.uniprot.org/citations/12236595 | http://purl.uniprot.org/core/author | "Lu S.-W."xsd:string |
| http://purl.uniprot.org/citations/12236595 | http://purl.uniprot.org/core/author | "Rose M.S."xsd:string |
| http://purl.uniprot.org/citations/12236595 | http://purl.uniprot.org/core/author | "Rose M.S."xsd:string |
| http://purl.uniprot.org/citations/12236595 | http://purl.uniprot.org/core/author | "Yun S.-H."xsd:string |
| http://purl.uniprot.org/citations/12236595 | http://purl.uniprot.org/core/author | "Yun S.-H."xsd:string |
| http://purl.uniprot.org/citations/12236595 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12236595 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12236595 | http://purl.uniprot.org/core/name | "Mol. Plant Microbe Interact."xsd:string |
| http://purl.uniprot.org/citations/12236595 | http://purl.uniprot.org/core/name | "Mol. Plant Microbe Interact."xsd:string |
| http://purl.uniprot.org/citations/12236595 | http://purl.uniprot.org/core/pages | "883-893"xsd:string |
| http://purl.uniprot.org/citations/12236595 | http://purl.uniprot.org/core/pages | "883-893"xsd:string |
| http://purl.uniprot.org/citations/12236595 | http://purl.uniprot.org/core/title | "A decarboxylase encoded at the Cochliobolus heterostrophus translocation-associated Tox1B locus is required for polyketide (T-toxin) biosynthesis and high virulence on T-cytoplasm maize."xsd:string |
| http://purl.uniprot.org/citations/12236595 | http://purl.uniprot.org/core/title | "A decarboxylase encoded at the Cochliobolus heterostrophus translocation-associated Tox1B locus is required for polyketide (T-toxin) biosynthesis and high virulence on T-cytoplasm maize."xsd:string |