| http://purl.uniprot.org/citations/12239156 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12239156 | http://www.w3.org/2000/01/rdf-schema#comment | "Fanconi anemia is an autosomal recessive disorder characterized by aplastic anemia, cancer susceptibility, and cellular sensitivity to mitomycin C. The 6 known Fanconi anemia gene products (FANCA, FANCC, FANCD2, FANCE, FANCF, and FANCG proteins) interact in a common pathway. The monoubiquitination and nuclear foci formation of FANCD2 are essential for the function of this pathway. FANCA, FANCC, FANCG, and FANCF proteins form a multisubunit nuclear complex (FA complex) required for FANCD2 monoubiquitination. Because FANCE and FANCC interact in vitro and FANCE is required for FANCD2 monoubiquitination, we reasoned that FANCE is a component of the FA complex in vivo. Here we demonstrate that retroviral transduction of Fanconi anemia subtype E (FA-E) cells with the FANCE cDNA restores the nuclear accumulation of FANCC protein, FANCA-FANCC complex formation, monoubiquitination and nuclear foci formation of FANCD2, and mitomycin C resistance. Hemagglutinin (HA)-tagged FANCE protein localizes diffusely in the nucleus. In normal cells, HA-tagged FANCE protein coimmunoprecipitates with FANCA, FANCC, and FANCG but not with FANCD2. Our data indicate that FANCE is a component of the nuclear FA complex in vivo and is required for the monoubiquitination of FANCD2 and the downstream events in the FA pathway."xsd:string |
| http://purl.uniprot.org/citations/12239156 | http://purl.org/dc/terms/identifier | "doi:10.1182/blood-2002-03-0860"xsd:string |
| http://purl.uniprot.org/citations/12239156 | http://purl.uniprot.org/core/author | "D'Andrea A.D."xsd:string |
| http://purl.uniprot.org/citations/12239156 | http://purl.uniprot.org/core/author | "Taniguchi T."xsd:string |
| http://purl.uniprot.org/citations/12239156 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12239156 | http://purl.uniprot.org/core/name | "Blood"xsd:string |
| http://purl.uniprot.org/citations/12239156 | http://purl.uniprot.org/core/pages | "2457-2462"xsd:string |
| http://purl.uniprot.org/citations/12239156 | http://purl.uniprot.org/core/title | "The Fanconi anemia protein, FANCE, promotes the nuclear accumulation of FANCC."xsd:string |
| http://purl.uniprot.org/citations/12239156 | http://purl.uniprot.org/core/volume | "100"xsd:string |
| http://purl.uniprot.org/citations/12239156 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12239156 |
| http://purl.uniprot.org/citations/12239156 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/12239156 |
| http://purl.uniprot.org/uniprot/#_A0A087WW44-mappedCitation-12239156 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12239156 |
| http://purl.uniprot.org/uniprot/#_A0A024R9N2-mappedCitation-12239156 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12239156 |
| http://purl.uniprot.org/uniprot/#_A0A0S2Z3N5-mappedCitation-12239156 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12239156 |
| http://purl.uniprot.org/uniprot/#_B4E3W2-mappedCitation-12239156 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12239156 |
| http://purl.uniprot.org/uniprot/#_Q00597-mappedCitation-12239156 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12239156 |
| http://purl.uniprot.org/uniprot/#_Q9HB96-mappedCitation-12239156 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12239156 |
| http://purl.uniprot.org/uniprot/Q9HB96 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/12239156 |
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| http://purl.uniprot.org/uniprot/A0A024R9N2 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/12239156 |
| http://purl.uniprot.org/uniprot/Q00597 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/12239156 |
| http://purl.uniprot.org/uniprot/A0A0S2Z3N5 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/12239156 |
| http://purl.uniprot.org/uniprot/A0A087WW44 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/12239156 |