| http://purl.uniprot.org/citations/12239590 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12239590 | http://www.w3.org/2000/01/rdf-schema#comment | "Our objectives were to determine whether heme oxygenase-1 is a second messenger for prolactin-mediated angiogenesis. Endothelial cell proliferation and angiogenesis assay demonstrated that cell number and capillary formation were increased by prolactin (10 and 25 ng/ml). Both protein synthesis and mRNA analysis confirmed that HO-1 expression was induced by prolactin in cultured endothelial cells and occurred in a concentration-dependent manner. Endothelial cells transduced with retrovirus-mediated delivery of HO-1 gene in sense and antisense orientation were used to further determine whether HO-1 overexpression or underexpression modulated prolactin-mediated endothelial cell proliferation and angiogenesis. Incubation of human microvessel endothelial cells transduced with HO-1 in sense orientation resulted in enhancement of prolactin-mediated increase in endothelial cell proliferation and angiogenesis, whereas inhibition of HO-1 by transduction of HO-1 in antisense orientation prevented prolactin increase in endothelial cell proliferation. Similarly, addition of stannic mesoporphyrin, the inhibitor of HO activity, prevented PRL-mediated increase in endothelial cell proliferation. Our results demonstrated for the first time, that prolactin-mediated angiogenesis and cell proliferation was dependent on HO-1 gene expression."xsd:string |
| http://purl.uniprot.org/citations/12239590 | http://purl.uniprot.org/core/author | "Quan S."xsd:string |
| http://purl.uniprot.org/citations/12239590 | http://purl.uniprot.org/core/author | "Yang L."xsd:string |
| http://purl.uniprot.org/citations/12239590 | http://purl.uniprot.org/core/author | "Kappas A."xsd:string |
| http://purl.uniprot.org/citations/12239590 | http://purl.uniprot.org/core/author | "Mezentsev A.V."xsd:string |
| http://purl.uniprot.org/citations/12239590 | http://purl.uniprot.org/core/author | "Kushida T."xsd:string |
| http://purl.uniprot.org/citations/12239590 | http://purl.uniprot.org/core/author | "Abraham N.G."xsd:string |
| http://purl.uniprot.org/citations/12239590 | http://purl.uniprot.org/core/author | "Ghattas M.H."xsd:string |
| http://purl.uniprot.org/citations/12239590 | http://purl.uniprot.org/core/author | "Malaguarnera L."xsd:string |
| http://purl.uniprot.org/citations/12239590 | http://purl.uniprot.org/core/author | "Pilastro M.R."xsd:string |
| http://purl.uniprot.org/citations/12239590 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12239590 | http://purl.uniprot.org/core/name | "Int J Mol Med"xsd:string |
| http://purl.uniprot.org/citations/12239590 | http://purl.uniprot.org/core/pages | "433-440"xsd:string |
| http://purl.uniprot.org/citations/12239590 | http://purl.uniprot.org/core/title | "Significance of heme oxygenase in prolactin-mediated cell proliferation and angiogenesis in human endothelial cells."xsd:string |
| http://purl.uniprot.org/citations/12239590 | http://purl.uniprot.org/core/volume | "10"xsd:string |
| http://purl.uniprot.org/citations/12239590 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12239590 |
| http://purl.uniprot.org/citations/12239590 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/12239590 |
| http://purl.uniprot.org/uniprot/P09601#attribution-E98A9A5ED3F05F4AA4149DC0E7B5FD96 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/12239590 |