| http://purl.uniprot.org/citations/12270690 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12270690 | http://www.w3.org/2000/01/rdf-schema#comment | "Recently an aspartyl protease with beta-secretase activity called BACE was identified. In the present paper we showed that BACE is modulated by the oxidative stress product 4-hydroxynonenal (HNE). Exposure of NT(2) neurons to the two classical pro-oxidant stimuli ascorbate/FeSO(4) and H(2)O(2)/FeSO(4) resulted in a significant generation of HNE, which is temporally followed by an increased production of BACE protein levels. HNE mediated BACE induction is accompanied by a proportional elevation of carboxy-terminal fragments of amyloid precursor protein. Moreover, the direct relationship between BACE induction and lipid peroxidation products was strongly confirmed by the protection exerted by a short pretreatment with alpha-tocopherol, the most important antioxidant known to prevent the formation of aldehydic end-products of lipid peroxidation, including HNE. Our results support the hypothesis that oxidative stress and A beta production are strictly interrelated events and suggest that inhibition of BACE may have a therapeutic effect synergic with antioxidant compounds."xsd:string |
| http://purl.uniprot.org/citations/12270690 | http://purl.org/dc/terms/identifier | "doi:10.1006/nbdi.2002.0515"xsd:string |
| http://purl.uniprot.org/citations/12270690 | http://purl.uniprot.org/core/author | "Tabaton M."xsd:string |
| http://purl.uniprot.org/citations/12270690 | http://purl.uniprot.org/core/author | "Smith M.A."xsd:string |
| http://purl.uniprot.org/citations/12270690 | http://purl.uniprot.org/core/author | "Vitali A."xsd:string |
| http://purl.uniprot.org/citations/12270690 | http://purl.uniprot.org/core/author | "Borghi R."xsd:string |
| http://purl.uniprot.org/citations/12270690 | http://purl.uniprot.org/core/author | "Perry G."xsd:string |
| http://purl.uniprot.org/citations/12270690 | http://purl.uniprot.org/core/author | "Pronzato M.A."xsd:string |
| http://purl.uniprot.org/citations/12270690 | http://purl.uniprot.org/core/author | "Zaccheo D."xsd:string |
| http://purl.uniprot.org/citations/12270690 | http://purl.uniprot.org/core/author | "Bardini P."xsd:string |
| http://purl.uniprot.org/citations/12270690 | http://purl.uniprot.org/core/author | "Danni O."xsd:string |
| http://purl.uniprot.org/citations/12270690 | http://purl.uniprot.org/core/author | "Obbili A."xsd:string |
| http://purl.uniprot.org/citations/12270690 | http://purl.uniprot.org/core/author | "Tamagno E."xsd:string |
| http://purl.uniprot.org/citations/12270690 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12270690 | http://purl.uniprot.org/core/name | "Neurobiol Dis"xsd:string |
| http://purl.uniprot.org/citations/12270690 | http://purl.uniprot.org/core/pages | "279-288"xsd:string |
| http://purl.uniprot.org/citations/12270690 | http://purl.uniprot.org/core/title | "Oxidative stress increases expression and activity of BACE in NT2 neurons."xsd:string |
| http://purl.uniprot.org/citations/12270690 | http://purl.uniprot.org/core/volume | "10"xsd:string |
| http://purl.uniprot.org/citations/12270690 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12270690 |
| http://purl.uniprot.org/citations/12270690 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/12270690 |
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| http://purl.uniprot.org/uniprot/#_B7Z3Z4-mappedCitation-12270690 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12270690 |