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| http://purl.uniprot.org/citations/12270929 | http://www.w3.org/2000/01/rdf-schema#comment | "Inhibitor-2 (I-2) bound protein phosphatase-1 (PP1) and several PP1-binding proteins from rat brain extracts, including the actin-binding proteins, neurabin I and neurabin II. Neurabins from rat brain lysates were sedimented by I-2 and its structural homologue, I-4. The central domain of both neurabins bound PP1 and I-2, and mutation of a conserved PP1-binding motif abolished neurabin binding to both proteins. Microcystin-LR, a PP1 inhibitor, also attenuated I-2 binding to neurabins. Immunoprecipitation of neurabin I established its association with PP1 and I-2 in HEK293T cells and suggested that PP1 mediated I-2 binding to neurabins. The C terminus of I-2, although not required for PP1 binding, facilitated PP1 recruitment by neurabins, which also targeted I-2 to polymerized F-actin. Mutations that attenuated PP1 binding to I-2 and neurabin I suggested distinct and overlapping sites for these two proteins on the PP1 catalytic subunit. Immunocytochemistry in epithelial cells and cultured hippocampal neurons showed that endogenous neurabin II and I-2 colocalized at actin-rich structures, consistent with the ability of neurabins to target the PP1.I-2 complex to actin cytoskeleton and regulate cell morphology."xsd:string |
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| http://purl.uniprot.org/citations/12270929 | http://purl.uniprot.org/core/author | "Brautigan D.L."xsd:string |
| http://purl.uniprot.org/citations/12270929 | http://purl.uniprot.org/core/author | "Terry-Lorenzo R.T."xsd:string |
| http://purl.uniprot.org/citations/12270929 | http://purl.uniprot.org/core/author | "Shenolikar S."xsd:string |
| http://purl.uniprot.org/citations/12270929 | http://purl.uniprot.org/core/author | "Prickett T.D."xsd:string |
| http://purl.uniprot.org/citations/12270929 | http://purl.uniprot.org/core/author | "Elliot E."xsd:string |
| http://purl.uniprot.org/citations/12270929 | http://purl.uniprot.org/core/author | "Weiser D.C."xsd:string |
| http://purl.uniprot.org/citations/12270929 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12270929 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/12270929 | http://purl.uniprot.org/core/pages | "46535-46543"xsd:string |
| http://purl.uniprot.org/citations/12270929 | http://purl.uniprot.org/core/title | "Neurabins recruit protein phosphatase-1 and inhibitor-2 to the actin cytoskeleton."xsd:string |
| http://purl.uniprot.org/citations/12270929 | http://purl.uniprot.org/core/volume | "277"xsd:string |
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