| http://purl.uniprot.org/citations/12270937 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12270937 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12270937 | http://www.w3.org/2000/01/rdf-schema#comment | "X-linked ectodermal dysplasia receptor (XEDAR) is a recently isolated member of the tumor necrosis factor receptor family that has been shown to be highly expressed in ectodermal derivatives during embryonic development and binds to ectodysplasin-A2 (EDA-A2). By using a subclone of 293F cells with stable expression of XEDAR, we report that XEDAR activates the NF-kappaB and JNK pathways in an EDA-A2-dependent fashion. Treatment with EDA-A2 leads to the recruitment of TRAF3 and -6 to the aggregated XEDAR complex, suggesting a central role of these adaptors in the proximal aspect of XEDAR signaling. Whereas TRAF3 and -6, IKK1/IKKalpha, IKK2/IKKbeta, and NEMO/IKKgamma are involved in XEDAR-induced NF-kappaB activation, XEDAR-induced JNK activation seems to be mediated via a pathway dependent on TRAF3, TRAF6, and ASK1. Deletion and point mutagenesis studies delineate two distinct regions in the cytoplasmic domain of XEDAR, which are involved in binding to TRAF3 and -6, respectively, and play a major role in the activation of the NF-kappaB and JNK pathways. Taken together, our results establish a major role of TRAF3 and -6 in XEDAR signaling and in the process of ectodermal differentiation."xsd:string |
| http://purl.uniprot.org/citations/12270937 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m207923200"xsd:string |
| http://purl.uniprot.org/citations/12270937 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m207923200"xsd:string |
| http://purl.uniprot.org/citations/12270937 | http://purl.uniprot.org/core/author | "Zachariah S."xsd:string |
| http://purl.uniprot.org/citations/12270937 | http://purl.uniprot.org/core/author | "Zachariah S."xsd:string |
| http://purl.uniprot.org/citations/12270937 | http://purl.uniprot.org/core/author | "Shindo M."xsd:string |
| http://purl.uniprot.org/citations/12270937 | http://purl.uniprot.org/core/author | "Shindo M."xsd:string |
| http://purl.uniprot.org/citations/12270937 | http://purl.uniprot.org/core/author | "Chaudhary P.M."xsd:string |
| http://purl.uniprot.org/citations/12270937 | http://purl.uniprot.org/core/author | "Chaudhary P.M."xsd:string |
| http://purl.uniprot.org/citations/12270937 | http://purl.uniprot.org/core/author | "Sinha S.K."xsd:string |
| http://purl.uniprot.org/citations/12270937 | http://purl.uniprot.org/core/author | "Sinha S.K."xsd:string |
| http://purl.uniprot.org/citations/12270937 | http://purl.uniprot.org/core/author | "Quinones H.I."xsd:string |
| http://purl.uniprot.org/citations/12270937 | http://purl.uniprot.org/core/author | "Quinones H.I."xsd:string |
| http://purl.uniprot.org/citations/12270937 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12270937 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12270937 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/12270937 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/12270937 | http://purl.uniprot.org/core/pages | "44953-44961"xsd:string |
| http://purl.uniprot.org/citations/12270937 | http://purl.uniprot.org/core/pages | "44953-44961"xsd:string |
| http://purl.uniprot.org/citations/12270937 | http://purl.uniprot.org/core/title | "Role of TRAF3 and -6 in the activation of the NF-kappa B and JNK pathways by X-linked ectodermal dysplasia receptor."xsd:string |
| http://purl.uniprot.org/citations/12270937 | http://purl.uniprot.org/core/title | "Role of TRAF3 and -6 in the activation of the NF-kappa B and JNK pathways by X-linked ectodermal dysplasia receptor."xsd:string |
| http://purl.uniprot.org/citations/12270937 | http://purl.uniprot.org/core/volume | "277"xsd:string |
| http://purl.uniprot.org/citations/12270937 | http://purl.uniprot.org/core/volume | "277"xsd:string |