| http://purl.uniprot.org/citations/12296377 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12296377 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12296377 | http://www.w3.org/2000/01/rdf-schema#comment | "The human RNA methyltransferase like 1 gene (RNMTL1) is one of thirteen newly discovered genes within a 116 Kb segment of the chromosome 17p13.3 that suffers from a high frequent loss of heterozygosity in human hepatocellular carcinoma in China[1-5]. To understand the molecular mechanisms underlying transcription control of the RNMTL1 gene in human cancers, we decline using of the conventional approach where the cis-elements bound by the known transcription factors are primary targets, and carried out the systematic analyses to dissect the promoter structure and identify/characterize the key cis-elements that are responsible for its strong expression in cell. The molecular approaches applied included 1, the primer extension for mapping of the transcription starts; 2, the transient transfection/reporter assays on a large number of deletion and site-specific mutants of the promoter segment for defining the minimal promoter and the crucial elements within; and 3, the electrophoresis mobility shift assay with specific antibodies for reconfirming the nature of the transcription factors and their cognate cis-elements. We have shown that the interaction of an ATF/CREB element (-38 to -31) and its cognate transcription factors play a predominant role in the promoter activity of the RNMTL1 gene. The secondary DNA structures of the ATF/CREB element play a more vital role in the protein-DNA interaction. Finally, we reported a novel mechanism underlying the YY1 mediated transcription repression, namely, the ATF/CREB dependent transcription-repression by YY1 is executed in absence of its own sequence-specific binding."xsd:string |
| http://purl.uniprot.org/citations/12296377 | http://purl.org/dc/terms/identifier | "doi:10.1038/sj.cr.7290124"xsd:string |
| http://purl.uniprot.org/citations/12296377 | http://purl.org/dc/terms/identifier | "doi:10.1038/sj.cr.7290124"xsd:string |
| http://purl.uniprot.org/citations/12296377 | http://purl.uniprot.org/core/author | "Xu J."xsd:string |
| http://purl.uniprot.org/citations/12296377 | http://purl.uniprot.org/core/author | "Xu J."xsd:string |
| http://purl.uniprot.org/citations/12296377 | http://purl.uniprot.org/core/author | "Gu J.R."xsd:string |
| http://purl.uniprot.org/citations/12296377 | http://purl.uniprot.org/core/author | "Gu J.R."xsd:string |
| http://purl.uniprot.org/citations/12296377 | http://purl.uniprot.org/core/author | "Ni M."xsd:string |
| http://purl.uniprot.org/citations/12296377 | http://purl.uniprot.org/core/author | "Ni M."xsd:string |
| http://purl.uniprot.org/citations/12296377 | http://purl.uniprot.org/core/author | "Wan F."xsd:string |
| http://purl.uniprot.org/citations/12296377 | http://purl.uniprot.org/core/author | "Wan F."xsd:string |
| http://purl.uniprot.org/citations/12296377 | http://purl.uniprot.org/core/author | "De Zhu J."xsd:string |
| http://purl.uniprot.org/citations/12296377 | http://purl.uniprot.org/core/author | "De Zhu J."xsd:string |
| http://purl.uniprot.org/citations/12296377 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12296377 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12296377 | http://purl.uniprot.org/core/name | "Cell Res."xsd:string |
| http://purl.uniprot.org/citations/12296377 | http://purl.uniprot.org/core/name | "Cell Res."xsd:string |
| http://purl.uniprot.org/citations/12296377 | http://purl.uniprot.org/core/pages | "177-197"xsd:string |
| http://purl.uniprot.org/citations/12296377 | http://purl.uniprot.org/core/pages | "177-197"xsd:string |
| http://purl.uniprot.org/citations/12296377 | http://purl.uniprot.org/core/title | "The ATF/CREB site is the key element for transcription of the human RNA methyltransferase like 1(RNMTL1) gene, a newly discovered 17p13.3 gene."xsd:string |
| http://purl.uniprot.org/citations/12296377 | http://purl.uniprot.org/core/title | "The ATF/CREB site is the key element for transcription of the human RNA methyltransferase like 1(RNMTL1) gene, a newly discovered 17p13.3 gene."xsd:string |
| http://purl.uniprot.org/citations/12296377 | http://purl.uniprot.org/core/volume | "12"xsd:string |
| http://purl.uniprot.org/citations/12296377 | http://purl.uniprot.org/core/volume | "12"xsd:string |