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| http://purl.uniprot.org/citations/12297423 | http://www.w3.org/2000/01/rdf-schema#comment | "Toll-like receptors (TLRs), which recognize pathogen-associated molecular patterns and members of the proinflammatory interleukin-1 receptor (IL-1R) family, share homologies in their cytoplasmic domains. Engagement of members of both of these families initiates a common intracellular signaling cascade, in which MyD88 and tumor necrosis factor (TNF) receptor-associated factor 6 (TRAF6) are key adaptor proteins. Signaling between MyD88 and TRAF6 is mediated by members of the IL-1R-associated kinase (IRAK) family; however, the exact function of each IRAK protein remains controversial. IRAK-1 is required for the optimal transduction of IL-1R- and TLR-mediated signals, but IRAK-1 can be replaced by other IRAKs. Surprisingly, gene targeting studies show that the newest IRAK protein, IRAK-4, has an essential role in mediating signals initiated by IL-1R and TLR engagement. The kinase activity of IRAK-4 might be necessary to functionally modify IRAK-1 and perhaps other signal transducing substrates. Understanding the role of IRAK-4 in innate immunity will enable us to design novel strategies for therapeutic intervention in human infectious disease."xsd:string |
| http://purl.uniprot.org/citations/12297423 | http://purl.org/dc/terms/identifier | "doi:10.1016/s1471-4906(02)02298-6"xsd:string |
| http://purl.uniprot.org/citations/12297423 | http://purl.uniprot.org/core/author | "Suzuki S."xsd:string |
| http://purl.uniprot.org/citations/12297423 | http://purl.uniprot.org/core/author | "Suzuki N."xsd:string |
| http://purl.uniprot.org/citations/12297423 | http://purl.uniprot.org/core/author | "Yeh W.C."xsd:string |
| http://purl.uniprot.org/citations/12297423 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12297423 | http://purl.uniprot.org/core/name | "Trends Immunol"xsd:string |
| http://purl.uniprot.org/citations/12297423 | http://purl.uniprot.org/core/pages | "503-506"xsd:string |
| http://purl.uniprot.org/citations/12297423 | http://purl.uniprot.org/core/title | "IRAK-4 as the central TIR signaling mediator in innate immunity."xsd:string |
| http://purl.uniprot.org/citations/12297423 | http://purl.uniprot.org/core/volume | "23"xsd:string |
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