| http://purl.uniprot.org/citations/12297494 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12297494 | http://www.w3.org/2000/01/rdf-schema#comment | "Neuronal leucine-rich repeat protein-3 (NLRR-3) belongs to the LRR superfamily. Expression of rat NLRR-3 gene isolated from c-Ha-ras transgenic rat tumor is regulated mainly through the Ras-MAPK signaling pathway. NLRR-3 was found to enhance phosphorylation of MAPK when COS-7 cells were transfected with NLRR-3 and stimulated with a low concentration (0.01 ng/ml) of epidermal growth factor (EGF), but the amplification of MAPK phosphorylation by NLRR-3 was no longer observed when the carboxyl-terminal 30 amino acid stretch containing clathrin-mediated endocytosis motifs was deleted. A green fluorescent protein-tagged NLRR-3 localized at the plasma membrane was efficiently internalized in COS-7 cells, but internalization of a carboxyl-terminal-deleted version (NLRRDeltaC) was less efficient. The presence of clathrin-adaptor protein complexes containing NLRR-3 in brain lysate was confirmed by immunoprecipitation and glutathione S-transferase pull-down experiments, and affinity column chromatography revealed that the carboxyl-terminal region of NLRR-3 interacts with beta-adaptin. We propose that NLRR-3 potentiates Ras-MAPK signaling by facilitating internalization of EGF in clathrin-coated vesicles."xsd:string |
| http://purl.uniprot.org/citations/12297494 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.c200502200"xsd:string |
| http://purl.uniprot.org/citations/12297494 | http://purl.uniprot.org/core/author | "Ohno H."xsd:string |
| http://purl.uniprot.org/citations/12297494 | http://purl.uniprot.org/core/author | "Matsuoka Y."xsd:string |
| http://purl.uniprot.org/citations/12297494 | http://purl.uniprot.org/core/author | "Hamaguchi T."xsd:string |
| http://purl.uniprot.org/citations/12297494 | http://purl.uniprot.org/core/author | "Tsuda H."xsd:string |
| http://purl.uniprot.org/citations/12297494 | http://purl.uniprot.org/core/author | "Fukamachi K."xsd:string |
| http://purl.uniprot.org/citations/12297494 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12297494 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/12297494 | http://purl.uniprot.org/core/pages | "43549-43552"xsd:string |
| http://purl.uniprot.org/citations/12297494 | http://purl.uniprot.org/core/title | "Neuronal leucine-rich repeat protein-3 amplifies MAPK activation by epidermal growth factor through a carboxyl-terminal region containing endocytosis motifs."xsd:string |
| http://purl.uniprot.org/citations/12297494 | http://purl.uniprot.org/core/volume | "277"xsd:string |
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