| http://purl.uniprot.org/citations/12351676 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12351676 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12351676 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Citation |
| http://purl.uniprot.org/citations/12351676 | http://www.w3.org/2000/01/rdf-schema#comment | "Polycomb group (PcG) proteins play important roles in maintaining the silent state of HOX genes. Recent studies have implicated histone methylation in long-term gene silencing. However, a connection between PcG-mediated gene silencing and histone methylation has not been established. Here we report the purification and characterization of an EED-EZH2 complex, the human counterpart of the Drosophila ESC-E(Z) complex. We demonstrate that the complex specifically methylates nucleosomal histone H3 at lysine 27 (H3-K27). Using chromatin immunoprecipitation assays, we show that H3-K27 methylation colocalizes with, and is dependent on, E(Z) binding at an Ultrabithorax (Ubx) Polycomb response element (PRE), and that this methylation correlates with Ubx repression. Methylation on H3-K27 facilitates binding of Polycomb (PC), a component of the PRC1 complex, to histone H3 amino-terminal tail. Thus, these studies establish a link between histone methylation and PcG-mediated gene silencing."xsd:string |
| http://purl.uniprot.org/citations/12351676 | http://purl.org/dc/terms/identifier | "doi:10.1126/science.1076997"xsd:string |
| http://purl.uniprot.org/citations/12351676 | http://purl.org/dc/terms/identifier | "doi:10.1126/science.1076997"xsd:string |
| http://purl.uniprot.org/citations/12351676 | http://purl.org/dc/terms/identifier | "doi:10.1126/science.1076997"xsd:string |
| http://purl.uniprot.org/citations/12351676 | http://purl.uniprot.org/core/author | "Zhang Y."xsd:string |
| http://purl.uniprot.org/citations/12351676 | http://purl.uniprot.org/core/author | "Zhang Y."xsd:string |
| http://purl.uniprot.org/citations/12351676 | http://purl.uniprot.org/core/author | "Wang L."xsd:string |
| http://purl.uniprot.org/citations/12351676 | http://purl.uniprot.org/core/author | "Wang L."xsd:string |
| http://purl.uniprot.org/citations/12351676 | http://purl.uniprot.org/core/author | "Wang H."xsd:string |
| http://purl.uniprot.org/citations/12351676 | http://purl.uniprot.org/core/author | "Wang H."xsd:string |
| http://purl.uniprot.org/citations/12351676 | http://purl.uniprot.org/core/author | "Xia L."xsd:string |
| http://purl.uniprot.org/citations/12351676 | http://purl.uniprot.org/core/author | "Xia L."xsd:string |
| http://purl.uniprot.org/citations/12351676 | http://purl.uniprot.org/core/author | "Tempst P."xsd:string |
| http://purl.uniprot.org/citations/12351676 | http://purl.uniprot.org/core/author | "Tempst P."xsd:string |
| http://purl.uniprot.org/citations/12351676 | http://purl.uniprot.org/core/author | "Erdjument-Bromage H."xsd:string |
| http://purl.uniprot.org/citations/12351676 | http://purl.uniprot.org/core/author | "Erdjument-Bromage H."xsd:string |
| http://purl.uniprot.org/citations/12351676 | http://purl.uniprot.org/core/author | "Cao R."xsd:string |
| http://purl.uniprot.org/citations/12351676 | http://purl.uniprot.org/core/author | "Cao R."xsd:string |
| http://purl.uniprot.org/citations/12351676 | http://purl.uniprot.org/core/author | "Jones R.S."xsd:string |
| http://purl.uniprot.org/citations/12351676 | http://purl.uniprot.org/core/author | "Jones R.S."xsd:string |
| http://purl.uniprot.org/citations/12351676 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12351676 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |