| http://purl.uniprot.org/citations/12351722 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12351722 | http://www.w3.org/2000/01/rdf-schema#comment | "Dopaminergic transmission within limbic regions of the brain is highly dependent on the regulation of D2 receptor activity. Here we show that the neuronal calcium sensor-1 (NCS-1) can mediate desensitization of D2 dopamine receptors. Analysis of D2 receptors expressed in human embryonic kidney 293 cells indicates that NCS-1 attenuates agonist-induced receptor internalization via a mechanism that involves a reduction in D2 receptor phosphorylation. This effect of NCS-1 was accompanied by an increase in D2 receptor-mediated cAMP inhibition after dopamine stimulation. The ability of NCS-1 to modulate D2 receptor signaling was abolished after a single amino acid mutation in NCS-1 that has been shown to impair the calcium-binding properties of NCS-1. Coimmunoprecipitation experiments from striatal neurons reveal that NCS-1 is found in association with both the D2 receptor and G-protein-coupled receptor kinase 2, a regulator of D2 receptor desensitization. Colocalization of NCS-1 and D2 receptors was examined in both primate and rodent brain. In striatum, NCS-1 and D2 receptors were found to colocalize within sites of synaptic transmission and in close proximity to intracellular calcium stores. NCS-1-D2 receptor interaction may serve to couple dopamine and calcium signaling pathways, thereby providing a critical component in the regulation of dopaminergic signaling in normal and diseased brain."xsd:string |
| http://purl.uniprot.org/citations/12351722 | http://purl.org/dc/terms/identifier | "doi:10.1523/jneurosci.22-19-08476.2002"xsd:string |
| http://purl.uniprot.org/citations/12351722 | http://purl.uniprot.org/core/author | "Levenson R."xsd:string |
| http://purl.uniprot.org/citations/12351722 | http://purl.uniprot.org/core/author | "Lin R."xsd:string |
| http://purl.uniprot.org/citations/12351722 | http://purl.uniprot.org/core/author | "Goldman-Rakic P."xsd:string |
| http://purl.uniprot.org/citations/12351722 | http://purl.uniprot.org/core/author | "Negyessy L."xsd:string |
| http://purl.uniprot.org/citations/12351722 | http://purl.uniprot.org/core/author | "Kabbani N."xsd:string |
| http://purl.uniprot.org/citations/12351722 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12351722 | http://purl.uniprot.org/core/name | "J Neurosci"xsd:string |
| http://purl.uniprot.org/citations/12351722 | http://purl.uniprot.org/core/pages | "8476-8486"xsd:string |
| http://purl.uniprot.org/citations/12351722 | http://purl.uniprot.org/core/title | "Interaction with neuronal calcium sensor NCS-1 mediates desensitization of the D2 dopamine receptor."xsd:string |
| http://purl.uniprot.org/citations/12351722 | http://purl.uniprot.org/core/volume | "22"xsd:string |
| http://purl.uniprot.org/citations/12351722 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12351722 |
| http://purl.uniprot.org/citations/12351722 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/12351722 |
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| http://purl.uniprot.org/uniprot/A0A8I6GJM4 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/12351722 |