| http://purl.uniprot.org/citations/12353038 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12353038 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12353038 | http://www.w3.org/2000/01/rdf-schema#comment | "Lysine methylation of histones in vivo occurs in three states: mono-, di- and tri-methyl. Histone H3 has been found to be di-methylated at lysine 4 (K4) in active euchromatic regions but not in silent heterochromatic sites. Here we show that the Saccharomyces cerevisiae Set1 protein can catalyse di- and tri-methylation of K4 and stimulate the activity of many genes. Using antibodies that discriminate between the di- and tri-methylated state of K4 we show that di-methylation occurs at both inactive and active euchromatic genes, whereas tri-methylation is present exclusively at active genes. It is therefore the presence of a tri-methylated K4 that defines an active state of gene expression. These findings establish the concept of methyl status as a determinant for gene activity and thus extend considerably the complexity of histone modifications."xsd:string |
| http://purl.uniprot.org/citations/12353038 | http://purl.org/dc/terms/identifier | "doi:10.1038/nature01080"xsd:string |
| http://purl.uniprot.org/citations/12353038 | http://purl.org/dc/terms/identifier | "doi:10.1038/nature01080"xsd:string |
| http://purl.uniprot.org/citations/12353038 | http://purl.uniprot.org/core/author | "Kouzarides T."xsd:string |
| http://purl.uniprot.org/citations/12353038 | http://purl.uniprot.org/core/author | "Kouzarides T."xsd:string |
| http://purl.uniprot.org/citations/12353038 | http://purl.uniprot.org/core/author | "Schneider R."xsd:string |
| http://purl.uniprot.org/citations/12353038 | http://purl.uniprot.org/core/author | "Schneider R."xsd:string |
| http://purl.uniprot.org/citations/12353038 | http://purl.uniprot.org/core/author | "Bernstein B.E."xsd:string |
| http://purl.uniprot.org/citations/12353038 | http://purl.uniprot.org/core/author | "Bernstein B.E."xsd:string |
| http://purl.uniprot.org/citations/12353038 | http://purl.uniprot.org/core/author | "Schreiber S.L."xsd:string |
| http://purl.uniprot.org/citations/12353038 | http://purl.uniprot.org/core/author | "Schreiber S.L."xsd:string |
| http://purl.uniprot.org/citations/12353038 | http://purl.uniprot.org/core/author | "Bannister A.J."xsd:string |
| http://purl.uniprot.org/citations/12353038 | http://purl.uniprot.org/core/author | "Bannister A.J."xsd:string |
| http://purl.uniprot.org/citations/12353038 | http://purl.uniprot.org/core/author | "Mellor J."xsd:string |
| http://purl.uniprot.org/citations/12353038 | http://purl.uniprot.org/core/author | "Mellor J."xsd:string |
| http://purl.uniprot.org/citations/12353038 | http://purl.uniprot.org/core/author | "Santos-Rosa H."xsd:string |
| http://purl.uniprot.org/citations/12353038 | http://purl.uniprot.org/core/author | "Santos-Rosa H."xsd:string |
| http://purl.uniprot.org/citations/12353038 | http://purl.uniprot.org/core/author | "Emre N.C.T."xsd:string |
| http://purl.uniprot.org/citations/12353038 | http://purl.uniprot.org/core/author | "Emre N.C.T."xsd:string |
| http://purl.uniprot.org/citations/12353038 | http://purl.uniprot.org/core/author | "Sherriff J."xsd:string |
| http://purl.uniprot.org/citations/12353038 | http://purl.uniprot.org/core/author | "Sherriff J."xsd:string |
| http://purl.uniprot.org/citations/12353038 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12353038 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |