| http://purl.uniprot.org/citations/12354385 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12354385 | http://www.w3.org/2000/01/rdf-schema#comment | "After immunization with T cell-dependent antigens, the high-affinity B cells selected in germinal centers differentiate into memory B cells or long-lived antibody-forming cells. However, a role for germinal centers in development of these B lineage cells is still controversial. We show here that Bcl6-deficient B cells, which cannot develop germinal centers, differentiated into IgM and IgG1 memory B cells in the spleen but barely differentiated into long-lived IgG1 antibody-forming cells in the bone marrow. Mutation in the V-heavy gene was null in these memory B cells. Therefore, Bcl6 and germinal center formation are essential for somatic hypermutation, and generation of memory B cells can occur independently of germinal center formation, somatic hypermutation, and Ig class switching."xsd:string |
| http://purl.uniprot.org/citations/12354385 | http://purl.org/dc/terms/identifier | "doi:10.1016/s1074-7613(02)00387-4"xsd:string |
| http://purl.uniprot.org/citations/12354385 | http://purl.uniprot.org/core/author | "Okada S."xsd:string |
| http://purl.uniprot.org/citations/12354385 | http://purl.uniprot.org/core/author | "Takahashi Y."xsd:string |
| http://purl.uniprot.org/citations/12354385 | http://purl.uniprot.org/core/author | "Takeda N."xsd:string |
| http://purl.uniprot.org/citations/12354385 | http://purl.uniprot.org/core/author | "Toyama H."xsd:string |
| http://purl.uniprot.org/citations/12354385 | http://purl.uniprot.org/core/author | "Kuroda Y."xsd:string |
| http://purl.uniprot.org/citations/12354385 | http://purl.uniprot.org/core/author | "Tokuhisa T."xsd:string |
| http://purl.uniprot.org/citations/12354385 | http://purl.uniprot.org/core/author | "Hatano M."xsd:string |
| http://purl.uniprot.org/citations/12354385 | http://purl.uniprot.org/core/author | "Ichii H."xsd:string |
| http://purl.uniprot.org/citations/12354385 | http://purl.uniprot.org/core/author | "Takemori T."xsd:string |
| http://purl.uniprot.org/citations/12354385 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12354385 | http://purl.uniprot.org/core/name | "Immunity"xsd:string |
| http://purl.uniprot.org/citations/12354385 | http://purl.uniprot.org/core/pages | "329-339"xsd:string |
| http://purl.uniprot.org/citations/12354385 | http://purl.uniprot.org/core/title | "Memory B cells without somatic hypermutation are generated from Bcl6-deficient B cells."xsd:string |
| http://purl.uniprot.org/citations/12354385 | http://purl.uniprot.org/core/volume | "17"xsd:string |
| http://purl.uniprot.org/citations/12354385 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12354385 |
| http://purl.uniprot.org/citations/12354385 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/12354385 |
| http://purl.uniprot.org/uniprot/P41183#attribution-EB5D5205C7CA6B2E56DED02879DB5794 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/12354385 |
| http://purl.uniprot.org/uniprot/Q5ZM39#attribution-0383FCBEB68B284833E80671844B68D2 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/12354385 |
| http://purl.uniprot.org/uniprot/E1B8E6#attribution-0383FCBEB68B284833E80671844B68D2 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/12354385 |
| http://purl.uniprot.org/uniprot/Q5RB65#attribution-0383FCBEB68B284833E80671844B68D2 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/12354385 |
| http://purl.uniprot.org/uniprot/#_P15919-mappedCitation-12354385 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12354385 |
| http://purl.uniprot.org/uniprot/#_P41183-mappedCitation-12354385 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12354385 |