| http://purl.uniprot.org/citations/12354753 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12354753 | http://www.w3.org/2000/01/rdf-schema#comment | "Although K-ras is frequently mutated in lung adenocarcinomas, the normal function of K-ras p21 in lung is not known. In two mouse (E10 and C10) and one human (HPL1D) immortalized lung cell lines from peripheral epithelium, we have measured total K-ras p21 and active K-ras p21-GTP during cell proliferation and at growth arrest caused by confluence. In all three cell types, total K-ras p21 increased 2- to 4-fold at confluence, and active K-ras p21-GTP increased 10-to 200-fold. It was estimated that 0.03% of total K-ras p21 was in the active GTP-bound state at 50% confluence, compared with 1.4% at postconfluence. By contrast, stimulation of proliferation by serum-containing medium did not involve K-ras p21 activation, even though a rapid, marked activation of both Erk1/2 and Akt occurred. At confluence, large increases, up to 14-fold, were seen in Grb2/Sos1 complexes, which may activate K-ras p21. In sum, increased protein expression and activity of K-ras p21 are associated with growth arrest, not with proliferation, in mouse and human lung cell lines."xsd:string |
| http://purl.uniprot.org/citations/12354753 | http://purl.uniprot.org/core/author | "Takahashi T."xsd:string |
| http://purl.uniprot.org/citations/12354753 | http://purl.uniprot.org/core/author | "Masuda A."xsd:string |
| http://purl.uniprot.org/citations/12354753 | http://purl.uniprot.org/core/author | "Sithanandam G."xsd:string |
| http://purl.uniprot.org/citations/12354753 | http://purl.uniprot.org/core/author | "Smith G.T."xsd:string |
| http://purl.uniprot.org/citations/12354753 | http://purl.uniprot.org/core/author | "Anderson L.M."xsd:string |
| http://purl.uniprot.org/citations/12354753 | http://purl.uniprot.org/core/author | "Ramakrishna G."xsd:string |
| http://purl.uniprot.org/citations/12354753 | http://purl.uniprot.org/core/author | "Fornwald L.W."xsd:string |
| http://purl.uniprot.org/citations/12354753 | http://purl.uniprot.org/core/author | "Kammouni W."xsd:string |
| http://purl.uniprot.org/citations/12354753 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12354753 | http://purl.uniprot.org/core/name | "Cell Growth Differ"xsd:string |
| http://purl.uniprot.org/citations/12354753 | http://purl.uniprot.org/core/pages | "441-448"xsd:string |
| http://purl.uniprot.org/citations/12354753 | http://purl.uniprot.org/core/title | "Increased K-ras protein and activity in mouse and human lung epithelial cells at confluence."xsd:string |
| http://purl.uniprot.org/citations/12354753 | http://purl.uniprot.org/core/volume | "13"xsd:string |
| http://purl.uniprot.org/citations/12354753 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12354753 |
| http://purl.uniprot.org/citations/12354753 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/12354753 |
| http://purl.uniprot.org/uniprot/Q60631#attribution-458C3BA15D638D6D2AF0A60DA0A7949F | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/12354753 |
| http://purl.uniprot.org/uniprot/P32883#attribution-458C3BA15D638D6D2AF0A60DA0A7949F | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/12354753 |
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| http://purl.uniprot.org/uniprot/#_A0A0N4SWH5-mappedCitation-12354753 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12354753 |
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