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http://purl.uniprot.org/citations/12354791http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/12354791http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/12354791http://www.w3.org/2000/01/rdf-schema#comment"The toxicity of an abnormally long polyglutamine [poly(Q)] tract within specific proteins is the molecular lesion shared by Huntington's disease (HD) and several other hereditary neurodegenerative disorders. By a genetic screen in Drosophila, devised to uncover genes that suppress poly(Q) toxicity, we discovered a Drosophila homolog of human myeloid leukemia factor 1 (MLF1). Expression of the Drosophila homolog (dMLF) ameliorates the toxicity of poly(Q) expressed in the eye and central nervous system. In the retina, whether endogenously or ectopically expressed, dMLF co-localized with aggregates, suggesting that dMLF alone, or through an intermediary molecular partner, may suppress toxicity by sequestering poly(Q) and/or its aggregates."xsd:string
http://purl.uniprot.org/citations/12354791http://purl.org/dc/terms/identifier"doi:10.1093/hmg/11.21.2657"xsd:string
http://purl.uniprot.org/citations/12354791http://purl.org/dc/terms/identifier"doi:10.1093/hmg/11.21.2657"xsd:string
http://purl.uniprot.org/citations/12354791http://purl.uniprot.org/core/author"Benzer S."xsd:string
http://purl.uniprot.org/citations/12354791http://purl.uniprot.org/core/author"Benzer S."xsd:string
http://purl.uniprot.org/citations/12354791http://purl.uniprot.org/core/author"Kazemi-Esfarjani P."xsd:string
http://purl.uniprot.org/citations/12354791http://purl.uniprot.org/core/author"Kazemi-Esfarjani P."xsd:string
http://purl.uniprot.org/citations/12354791http://purl.uniprot.org/core/date"2002"xsd:gYear
http://purl.uniprot.org/citations/12354791http://purl.uniprot.org/core/date"2002"xsd:gYear
http://purl.uniprot.org/citations/12354791http://purl.uniprot.org/core/name"Hum. Mol. Genet."xsd:string
http://purl.uniprot.org/citations/12354791http://purl.uniprot.org/core/name"Hum. Mol. Genet."xsd:string
http://purl.uniprot.org/citations/12354791http://purl.uniprot.org/core/pages"2657-2672"xsd:string
http://purl.uniprot.org/citations/12354791http://purl.uniprot.org/core/pages"2657-2672"xsd:string
http://purl.uniprot.org/citations/12354791http://purl.uniprot.org/core/title"Suppression of polyglutamine toxicity by a Drosophila homolog of myeloid leukemia factor 1."xsd:string
http://purl.uniprot.org/citations/12354791http://purl.uniprot.org/core/title"Suppression of polyglutamine toxicity by a Drosophila homolog of myeloid leukemia factor 1."xsd:string
http://purl.uniprot.org/citations/12354791http://purl.uniprot.org/core/volume"11"xsd:string
http://purl.uniprot.org/citations/12354791http://purl.uniprot.org/core/volume"11"xsd:string
http://purl.uniprot.org/citations/12354791http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/12354791
http://purl.uniprot.org/citations/12354791http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/12354791
http://purl.uniprot.org/citations/12354791http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/12354791
http://purl.uniprot.org/citations/12354791http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/12354791
http://purl.uniprot.org/uniprot/Q9NKV0http://purl.uniprot.org/core/citationhttp://purl.uniprot.org/citations/12354791
http://purl.uniprot.org/uniprot/#_kb.Q9NKV0_up.isolatedFrom_tissue.436http://purl.uniprot.org/core/citationhttp://purl.uniprot.org/citations/12354791