http://purl.uniprot.org/citations/12354791 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
http://purl.uniprot.org/citations/12354791 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
http://purl.uniprot.org/citations/12354791 | http://www.w3.org/2000/01/rdf-schema#comment | "The toxicity of an abnormally long polyglutamine [poly(Q)] tract within specific proteins is the molecular lesion shared by Huntington's disease (HD) and several other hereditary neurodegenerative disorders. By a genetic screen in Drosophila, devised to uncover genes that suppress poly(Q) toxicity, we discovered a Drosophila homolog of human myeloid leukemia factor 1 (MLF1). Expression of the Drosophila homolog (dMLF) ameliorates the toxicity of poly(Q) expressed in the eye and central nervous system. In the retina, whether endogenously or ectopically expressed, dMLF co-localized with aggregates, suggesting that dMLF alone, or through an intermediary molecular partner, may suppress toxicity by sequestering poly(Q) and/or its aggregates."xsd:string |
http://purl.uniprot.org/citations/12354791 | http://purl.org/dc/terms/identifier | "doi:10.1093/hmg/11.21.2657"xsd:string |
http://purl.uniprot.org/citations/12354791 | http://purl.org/dc/terms/identifier | "doi:10.1093/hmg/11.21.2657"xsd:string |
http://purl.uniprot.org/citations/12354791 | http://purl.uniprot.org/core/author | "Benzer S."xsd:string |
http://purl.uniprot.org/citations/12354791 | http://purl.uniprot.org/core/author | "Benzer S."xsd:string |
http://purl.uniprot.org/citations/12354791 | http://purl.uniprot.org/core/author | "Kazemi-Esfarjani P."xsd:string |
http://purl.uniprot.org/citations/12354791 | http://purl.uniprot.org/core/author | "Kazemi-Esfarjani P."xsd:string |
http://purl.uniprot.org/citations/12354791 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
http://purl.uniprot.org/citations/12354791 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
http://purl.uniprot.org/citations/12354791 | http://purl.uniprot.org/core/name | "Hum. Mol. Genet."xsd:string |
http://purl.uniprot.org/citations/12354791 | http://purl.uniprot.org/core/name | "Hum. Mol. Genet."xsd:string |
http://purl.uniprot.org/citations/12354791 | http://purl.uniprot.org/core/pages | "2657-2672"xsd:string |
http://purl.uniprot.org/citations/12354791 | http://purl.uniprot.org/core/pages | "2657-2672"xsd:string |
http://purl.uniprot.org/citations/12354791 | http://purl.uniprot.org/core/title | "Suppression of polyglutamine toxicity by a Drosophila homolog of myeloid leukemia factor 1."xsd:string |
http://purl.uniprot.org/citations/12354791 | http://purl.uniprot.org/core/title | "Suppression of polyglutamine toxicity by a Drosophila homolog of myeloid leukemia factor 1."xsd:string |
http://purl.uniprot.org/citations/12354791 | http://purl.uniprot.org/core/volume | "11"xsd:string |
http://purl.uniprot.org/citations/12354791 | http://purl.uniprot.org/core/volume | "11"xsd:string |
http://purl.uniprot.org/citations/12354791 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12354791 |
http://purl.uniprot.org/citations/12354791 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12354791 |
http://purl.uniprot.org/citations/12354791 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/12354791 |
http://purl.uniprot.org/citations/12354791 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/12354791 |
http://purl.uniprot.org/uniprot/Q9NKV0 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/12354791 |
http://purl.uniprot.org/uniprot/#_kb.Q9NKV0_up.isolatedFrom_tissue.436 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/12354791 |