| http://purl.uniprot.org/citations/12356723 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12356723 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12356723 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Citation |
| http://purl.uniprot.org/citations/12356723 | http://www.w3.org/2000/01/rdf-schema#comment | "Phosphoinositides play a central role in the control of several cellular events including actin cytoskeleton organization. Here we show that, upon infection of epithelial cells with the Gram-negative pathogen Shigella flexneri, the virulence factor IpgD is translocated directly into eukaryotic cells and acts as a potent inositol 4-phosphatase that specifically dephosphorylates phosphatidylinositol 4,5-bisphosphate [PtdIns(4,5)P(2)] into phosphatidylinositol 5-monophosphate [PtdIns(5)P] that then accumulates. Transfection experiments indicate that the transformation of PtdIns(4,5)P(2) into PtdIns(5)P by IpgD is responsible for dramatic morphological changes of the host cell, leading to a decrease in membrane tether force associated with membrane blebbing and actin filament remodelling. These data provide the molecular basis for a new mechanism employed by a pathogenic bacterium to promote membrane ruffling at the entry site."xsd:string |
| http://purl.uniprot.org/citations/12356723 | http://purl.org/dc/terms/identifier | "doi:10.1093/emboj/cdf522"xsd:string |
| http://purl.uniprot.org/citations/12356723 | http://purl.org/dc/terms/identifier | "doi:10.1093/emboj/cdf522"xsd:string |
| http://purl.uniprot.org/citations/12356723 | http://purl.uniprot.org/core/author | "Philpott D.J."xsd:string |
| http://purl.uniprot.org/citations/12356723 | http://purl.uniprot.org/core/author | "Philpott D.J."xsd:string |
| http://purl.uniprot.org/citations/12356723 | http://purl.uniprot.org/core/author | "Niebuhr K."xsd:string |
| http://purl.uniprot.org/citations/12356723 | http://purl.uniprot.org/core/author | "Niebuhr K."xsd:string |
| http://purl.uniprot.org/citations/12356723 | http://purl.uniprot.org/core/author | "Parsot C."xsd:string |
| http://purl.uniprot.org/citations/12356723 | http://purl.uniprot.org/core/author | "Parsot C."xsd:string |
| http://purl.uniprot.org/citations/12356723 | http://purl.uniprot.org/core/author | "Sansonetti P.J."xsd:string |
| http://purl.uniprot.org/citations/12356723 | http://purl.uniprot.org/core/author | "Sansonetti P.J."xsd:string |
| http://purl.uniprot.org/citations/12356723 | http://purl.uniprot.org/core/author | "Gaits F."xsd:string |
| http://purl.uniprot.org/citations/12356723 | http://purl.uniprot.org/core/author | "Gaits F."xsd:string |
| http://purl.uniprot.org/citations/12356723 | http://purl.uniprot.org/core/author | "Sheetz M.P."xsd:string |
| http://purl.uniprot.org/citations/12356723 | http://purl.uniprot.org/core/author | "Sheetz M.P."xsd:string |
| http://purl.uniprot.org/citations/12356723 | http://purl.uniprot.org/core/author | "Payrastre B."xsd:string |
| http://purl.uniprot.org/citations/12356723 | http://purl.uniprot.org/core/author | "Payrastre B."xsd:string |
| http://purl.uniprot.org/citations/12356723 | http://purl.uniprot.org/core/author | "Giuriato S."xsd:string |
| http://purl.uniprot.org/citations/12356723 | http://purl.uniprot.org/core/author | "Giuriato S."xsd:string |
| http://purl.uniprot.org/citations/12356723 | http://purl.uniprot.org/core/author | "Pedron T."xsd:string |
| http://purl.uniprot.org/citations/12356723 | http://purl.uniprot.org/core/author | "Pedron T."xsd:string |
| http://purl.uniprot.org/citations/12356723 | http://purl.uniprot.org/core/author | "Sable J."xsd:string |