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http://purl.uniprot.org/citations/12359369http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/12359369http://www.w3.org/2000/01/rdf-schema#comment"In B-cell chronic lymphocytic leukemia (CLL) a high Bcl-2/Bax ratio contributes to death defiance. We sought to identify any genetic changes in the BAX as a possible mechanism for its altered expression in CLL. The BAX gene from the RL cell line and B-cells from 34 CLL patients and 25 controls were sequenced. A novel heterozygous G(-248)A polymorphism in the 5'-UTR was present in 69% of stage I-IV patients and 5.5% of stage 0 patients, and in 4.0% of controls. It was associated with reduced protein expression (P=0.049), progression beyond Rai stage 0 (P=0.00018) and failure to achieve complete response (P=0.038)."xsd:string
http://purl.uniprot.org/citations/12359369http://purl.org/dc/terms/identifier"doi:10.1016/s0304-3835(02)00378-6"xsd:string
http://purl.uniprot.org/citations/12359369http://purl.uniprot.org/core/author"Saxena A."xsd:string
http://purl.uniprot.org/citations/12359369http://purl.uniprot.org/core/author"Viswanathan S."xsd:string
http://purl.uniprot.org/citations/12359369http://purl.uniprot.org/core/author"Sankaran K."xsd:string
http://purl.uniprot.org/citations/12359369http://purl.uniprot.org/core/author"Moshynska O."xsd:string
http://purl.uniprot.org/citations/12359369http://purl.uniprot.org/core/author"Sheridan D.P."xsd:string
http://purl.uniprot.org/citations/12359369http://purl.uniprot.org/core/date"2002"xsd:gYear
http://purl.uniprot.org/citations/12359369http://purl.uniprot.org/core/name"Cancer Lett"xsd:string
http://purl.uniprot.org/citations/12359369http://purl.uniprot.org/core/pages"199-205"xsd:string
http://purl.uniprot.org/citations/12359369http://purl.uniprot.org/core/title"Association of a novel single nucleotide polymorphism, G(-248)A, in the 5'-UTR of BAX gene in chronic lymphocytic leukemia with disease progression and treatment resistance."xsd:string
http://purl.uniprot.org/citations/12359369http://purl.uniprot.org/core/volume"187"xsd:string
http://purl.uniprot.org/citations/12359369http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/12359369
http://purl.uniprot.org/citations/12359369http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/12359369
http://purl.uniprot.org/uniprot/#_A0A0C4MVT1-mappedCitation-12359369http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/12359369
http://purl.uniprot.org/uniprot/#_A0A0C4MW46-mappedCitation-12359369http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/12359369
http://purl.uniprot.org/uniprot/#_A0A0C4MWS3-mappedCitation-12359369http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/12359369
http://purl.uniprot.org/uniprot/#_Q07812-mappedCitation-12359369http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/12359369
http://purl.uniprot.org/uniprot/#_Q5ZPJ0-mappedCitation-12359369http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/12359369
http://purl.uniprot.org/uniprot/#_Q5ZPJ1-mappedCitation-12359369http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/12359369
http://purl.uniprot.org/uniprot/#_I6LPK7-mappedCitation-12359369http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/12359369
http://purl.uniprot.org/uniprot/#_K4JQN1-mappedCitation-12359369http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/12359369
http://purl.uniprot.org/uniprot/#_O95074-mappedCitation-12359369http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/12359369
http://purl.uniprot.org/uniprot/#_Q8WXU1-mappedCitation-12359369http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/12359369