| http://purl.uniprot.org/citations/12363396 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12363396 | http://www.w3.org/2000/01/rdf-schema#comment | "Clozapine is a potent antagonist of 5-HT3 receptors, which are ligand-gated ion channels that mediate rapid excitatory responses in the central nervous system. Two different isoforms of 5-HT3 receptor subunit genes (HTR3A and HTR3B) have been identified. They have been assigned to chromosome 11q23.1-q23.2, a region which in the past has been linked to schizophrenia and bipolar disorder. In this study, we performed a systematic mutation screening of the 5-HT3A and 5-HT3B receptor genes and tested the variants for association with clozapine response in a sample of 266 clozapine-treated patients. Two polymorphisms at the 5-HT3A gene and five new variants in the 5-HT3B gene were finally detected. Of these, only the more frequent mutations (178-C/T and 1596-A/G in 5-HT3A and a CA-repeat in 5-HT3B) were genotyped in our clozapine sample. Association analysis showed similar allele and genotype distributions among clozapine responders and nonresponders. These results make unlikely the possibility that 5-HT3A and 5-HT3B receptor genes underlie variation in clinical response to clozapine. However, the promoter regions of both genes have yet to be investigated."xsd:string |
| http://purl.uniprot.org/citations/12363396 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0920-9964(02)00205-0"xsd:string |
| http://purl.uniprot.org/citations/12363396 | http://purl.uniprot.org/core/author | "Osborne S."xsd:string |
| http://purl.uniprot.org/citations/12363396 | http://purl.uniprot.org/core/author | "Gutierrez B."xsd:string |
| http://purl.uniprot.org/citations/12363396 | http://purl.uniprot.org/core/author | "Travis M."xsd:string |
| http://purl.uniprot.org/citations/12363396 | http://purl.uniprot.org/core/author | "Kerwin R.W."xsd:string |
| http://purl.uniprot.org/citations/12363396 | http://purl.uniprot.org/core/author | "Arranz M.J."xsd:string |
| http://purl.uniprot.org/citations/12363396 | http://purl.uniprot.org/core/author | "Munro J."xsd:string |
| http://purl.uniprot.org/citations/12363396 | http://purl.uniprot.org/core/author | "Dempster D."xsd:string |
| http://purl.uniprot.org/citations/12363396 | http://purl.uniprot.org/core/author | "Huezo-Diaz P."xsd:string |
| http://purl.uniprot.org/citations/12363396 | http://purl.uniprot.org/core/author | "Matthiasson P."xsd:string |
| http://purl.uniprot.org/citations/12363396 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12363396 | http://purl.uniprot.org/core/name | "Schizophr Res"xsd:string |
| http://purl.uniprot.org/citations/12363396 | http://purl.uniprot.org/core/pages | "93-97"xsd:string |
| http://purl.uniprot.org/citations/12363396 | http://purl.uniprot.org/core/title | "Novel mutations in 5-HT3A and 5-HT3B receptor genes not associated with clozapine response."xsd:string |
| http://purl.uniprot.org/citations/12363396 | http://purl.uniprot.org/core/volume | "58"xsd:string |
| http://purl.uniprot.org/citations/12363396 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12363396 |
| http://purl.uniprot.org/citations/12363396 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/12363396 |
| http://purl.uniprot.org/uniprot/#_A0A0B4J205-mappedCitation-12363396 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12363396 |
| http://purl.uniprot.org/uniprot/#_B2R9S2-mappedCitation-12363396 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12363396 |
| http://purl.uniprot.org/uniprot/#_B3VRG0-mappedCitation-12363396 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12363396 |
| http://purl.uniprot.org/uniprot/#_B3VRG5-mappedCitation-12363396 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12363396 |
| http://purl.uniprot.org/uniprot/#_B3VRH0-mappedCitation-12363396 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12363396 |
| http://purl.uniprot.org/uniprot/#_B3VRH5-mappedCitation-12363396 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12363396 |