| http://purl.uniprot.org/citations/12364336 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12364336 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12364336 | http://www.w3.org/2000/01/rdf-schema#comment | "Rab11-FIP2 is a member of a newly identified family of Rab11-binding proteins that have been implicated in the function of recycling endosomes. Here we show that Rab11-FIP2 may also be involved with the process of receptor-mediated endocytosis. First we demonstrate that Rab11-FIP2 contains an NPF motif that allows it to bind Reps1, a member of a family of EH domain proteins involved in endocytosis. We also show that Rab11-FIP2 associates with the alpha-adaptin subunit of AP-2 complexes, which are known to recruit receptors into clathrin-coated vesicles. Finally, we find that overexpression of Rab11-FIP2 suppresses the internalization of epidermal growth factor receptors, but not transferrin receptors, through binding sites that promote complex formation with Rab11, Reps1, and alpha-adaptin. These findings suggest that Rab11-FIP2 may participate in the coupling of receptor-mediated endocytosis to the subsequent sorting of receptor-containing vesicles in endosomes."xsd:string |
| http://purl.uniprot.org/citations/12364336 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m206316200"xsd:string |
| http://purl.uniprot.org/citations/12364336 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m206316200"xsd:string |
| http://purl.uniprot.org/citations/12364336 | http://purl.uniprot.org/core/author | "Feig L.A."xsd:string |
| http://purl.uniprot.org/citations/12364336 | http://purl.uniprot.org/core/author | "Feig L.A."xsd:string |
| http://purl.uniprot.org/citations/12364336 | http://purl.uniprot.org/core/author | "Baleja J.D."xsd:string |
| http://purl.uniprot.org/citations/12364336 | http://purl.uniprot.org/core/author | "Baleja J.D."xsd:string |
| http://purl.uniprot.org/citations/12364336 | http://purl.uniprot.org/core/author | "Cullis D.N."xsd:string |
| http://purl.uniprot.org/citations/12364336 | http://purl.uniprot.org/core/author | "Cullis D.N."xsd:string |
| http://purl.uniprot.org/citations/12364336 | http://purl.uniprot.org/core/author | "Philip B."xsd:string |
| http://purl.uniprot.org/citations/12364336 | http://purl.uniprot.org/core/author | "Philip B."xsd:string |
| http://purl.uniprot.org/citations/12364336 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12364336 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12364336 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/12364336 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/12364336 | http://purl.uniprot.org/core/pages | "49158-49166"xsd:string |
| http://purl.uniprot.org/citations/12364336 | http://purl.uniprot.org/core/pages | "49158-49166"xsd:string |
| http://purl.uniprot.org/citations/12364336 | http://purl.uniprot.org/core/title | "Rab11-FIP2, an adaptor protein connecting cellular components involved in internalization and recycling of epidermal growth factor receptors."xsd:string |
| http://purl.uniprot.org/citations/12364336 | http://purl.uniprot.org/core/title | "Rab11-FIP2, an adaptor protein connecting cellular components involved in internalization and recycling of epidermal growth factor receptors."xsd:string |
| http://purl.uniprot.org/citations/12364336 | http://purl.uniprot.org/core/volume | "277"xsd:string |
| http://purl.uniprot.org/citations/12364336 | http://purl.uniprot.org/core/volume | "277"xsd:string |
| http://purl.uniprot.org/citations/12364336 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12364336 |
| http://purl.uniprot.org/citations/12364336 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12364336 |