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http://purl.uniprot.org/citations/12368087http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/12368087http://www.w3.org/2000/01/rdf-schema#comment"Protein phosphorylation controls many cellular processes, especially those involved in intercellular communication and coordination of complex functions. To explore the evolution of protein phosphorylation, we compared the protein kinase complements ('kinomes') of budding yeast, worm and fly, with known human kinases. We classify kinases into putative orthologous groups with conserved functions and discuss kinase families and pathways that are unique, expanded or lost in each lineage. Fly and human share several kinase families involved in immunity, neurobiology, cell cycle and morphogenesis that are absent from worm, suggesting that these functions might have evolved after the divergence of nematodes from the main metazoan lineage."xsd:string
http://purl.uniprot.org/citations/12368087http://purl.org/dc/terms/identifier"doi:10.1016/s0968-0004(02)02179-5"xsd:string
http://purl.uniprot.org/citations/12368087http://purl.uniprot.org/core/author"Manning G."xsd:string
http://purl.uniprot.org/citations/12368087http://purl.uniprot.org/core/author"Hunter T."xsd:string
http://purl.uniprot.org/citations/12368087http://purl.uniprot.org/core/author"Sudarsanam S."xsd:string
http://purl.uniprot.org/citations/12368087http://purl.uniprot.org/core/author"Plowman G.D."xsd:string
http://purl.uniprot.org/citations/12368087http://purl.uniprot.org/core/date"2002"xsd:gYear
http://purl.uniprot.org/citations/12368087http://purl.uniprot.org/core/name"Trends Biochem Sci"xsd:string
http://purl.uniprot.org/citations/12368087http://purl.uniprot.org/core/pages"514-520"xsd:string
http://purl.uniprot.org/citations/12368087http://purl.uniprot.org/core/title"Evolution of protein kinase signaling from yeast to man."xsd:string
http://purl.uniprot.org/citations/12368087http://purl.uniprot.org/core/volume"27"xsd:string
http://purl.uniprot.org/citations/12368087http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/12368087
http://purl.uniprot.org/citations/12368087http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/12368087
http://purl.uniprot.org/uniprot/#_A0A0B4KHQ0-mappedCitation-12368087http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/12368087
http://purl.uniprot.org/uniprot/#_A0A0B4KHS6-mappedCitation-12368087http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/12368087
http://purl.uniprot.org/uniprot/#_A0A0B4KHS7-mappedCitation-12368087http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/12368087
http://purl.uniprot.org/uniprot/#_A0A0B4KHY4-mappedCitation-12368087http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/12368087
http://purl.uniprot.org/uniprot/#_A0A0B4LF75-mappedCitation-12368087http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/12368087
http://purl.uniprot.org/uniprot/#_E1JHK1-mappedCitation-12368087http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/12368087
http://purl.uniprot.org/uniprot/#_E1JHK2-mappedCitation-12368087http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/12368087
http://purl.uniprot.org/uniprot/#_P15330-mappedCitation-12368087http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/12368087
http://purl.uniprot.org/uniprot/#_A0A0B4K885-mappedCitation-12368087http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/12368087
http://purl.uniprot.org/uniprot/#_A0A0B4KH10-mappedCitation-12368087http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/12368087
http://purl.uniprot.org/uniprot/#_A1Z0H7-mappedCitation-12368087http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/12368087