| http://purl.uniprot.org/citations/12370279 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12370279 | http://www.w3.org/2000/01/rdf-schema#comment | "Defective insulin secretion is a feature of type 2 diabetes that results from inadequate compensatory increase of beta cell mass and impaired glucose-dependent insulin release. beta cell proliferation and secretion are thought to be regulated by signaling through receptor tyrosine kinases. In this regard, we sought to examine the potential proliferative and/or antiapoptotic role of IGFs in beta cells by tissue-specific conditional mutagenesis ablating type 1 IGF receptor (IGF1R) signaling. Unexpectedly, lack of functional IGF1R did not affect beta cell mass, but resulted in age-dependent impairment of glucose tolerance, associated with a decrease of glucose- and arginine-dependent insulin release. These observations reveal a requirement of IGF1R-mediated signaling for insulin secretion."xsd:string |
| http://purl.uniprot.org/citations/12370279 | http://purl.org/dc/terms/identifier | "doi:10.1172/jci15276"xsd:string |
| http://purl.uniprot.org/citations/12370279 | http://purl.uniprot.org/core/author | "Nakae J."xsd:string |
| http://purl.uniprot.org/citations/12370279 | http://purl.uniprot.org/core/author | "White M.F."xsd:string |
| http://purl.uniprot.org/citations/12370279 | http://purl.uniprot.org/core/author | "Kido Y."xsd:string |
| http://purl.uniprot.org/citations/12370279 | http://purl.uniprot.org/core/author | "Kitamura T."xsd:string |
| http://purl.uniprot.org/citations/12370279 | http://purl.uniprot.org/core/author | "Efstratiadis A."xsd:string |
| http://purl.uniprot.org/citations/12370279 | http://purl.uniprot.org/core/author | "Accili D."xsd:string |
| http://purl.uniprot.org/citations/12370279 | http://purl.uniprot.org/core/author | "Cinti S."xsd:string |
| http://purl.uniprot.org/citations/12370279 | http://purl.uniprot.org/core/author | "Fisher P.E."xsd:string |
| http://purl.uniprot.org/citations/12370279 | http://purl.uniprot.org/core/author | "Herrera P.L."xsd:string |
| http://purl.uniprot.org/citations/12370279 | http://purl.uniprot.org/core/author | "Politi K."xsd:string |
| http://purl.uniprot.org/citations/12370279 | http://purl.uniprot.org/core/author | "Xuan S."xsd:string |
| http://purl.uniprot.org/citations/12370279 | http://purl.uniprot.org/core/author | "Morroni M."xsd:string |
| http://purl.uniprot.org/citations/12370279 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12370279 | http://purl.uniprot.org/core/name | "J Clin Invest"xsd:string |
| http://purl.uniprot.org/citations/12370279 | http://purl.uniprot.org/core/pages | "1011-1019"xsd:string |
| http://purl.uniprot.org/citations/12370279 | http://purl.uniprot.org/core/title | "Defective insulin secretion in pancreatic beta cells lacking type 1 IGF receptor."xsd:string |
| http://purl.uniprot.org/citations/12370279 | http://purl.uniprot.org/core/volume | "110"xsd:string |
| http://purl.uniprot.org/citations/12370279 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12370279 |
| http://purl.uniprot.org/citations/12370279 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/12370279 |
| http://purl.uniprot.org/uniprot/#_E9QNX9-mappedCitation-12370279 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12370279 |
| http://purl.uniprot.org/uniprot/#_Q3UVJ3-mappedCitation-12370279 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12370279 |
| http://purl.uniprot.org/uniprot/#_Q60751-mappedCitation-12370279 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12370279 |