| http://purl.uniprot.org/citations/12370366 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12370366 | http://www.w3.org/2000/01/rdf-schema#comment | "FcgammaRIIB1 molecules serve as negative feedback regulator for B cell Ag receptor-elicited activation of B cells; thus, any impaired FcgammaRIIB1 function may possibly be related to aberrant B cell activation. We earlier found deletion polymorphism in the Fcgr2b promoter region among mouse strains in which systemic autoimmune disease-prone NZB, BXSB, MRL, and autoimmune diabetes-prone nonobese diabetic, but not NZW, BALB/c, and C57BL/6 mice have two identical deletion sites, consisting of 13 and 3 nucleotides. In this study, we established congenic C57BL/6 mice for NZB-type Fcgr2b allele and found that NZB-type allele down-regulates FcgammaRIIB1 expression levels in germinal center B cells and up-regulates IgG Ab responses. We did luciferase reporter assays to determine whether NZB-type deletion polymorphism affects transcriptional regulation of Fcgr2b gene. Although NZW- and BALB/c-derived segments from position -302 to +585 of Fcgr2b upstream region produced significant levels of luciferase activities, only a limited activity was detected in the NZB-derived sequence. EMSA and Southwestern analysis revealed that defect in transcription activity in the NZB-derived segment is likely due to absence of transactivation by AP-4, which binds to the polymorphic 13 nucleotide deletion site. Our data imply that because of the deficient AP-4 binding, the NZB-type Fcgr2b allele polymorphism results in up-regulation of IgG Ab responses through down-regulation of FcgammaRIIB1 expression levels in germinal center B cells, and that such polymorphism may possibly form the basis of autoimmune susceptibility in combination with other background contributing genes."xsd:string |
| http://purl.uniprot.org/citations/12370366 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.169.8.4340"xsd:string |
| http://purl.uniprot.org/citations/12370366 | http://purl.uniprot.org/core/author | "Jiang Y."xsd:string |
| http://purl.uniprot.org/citations/12370366 | http://purl.uniprot.org/core/author | "Li N."xsd:string |
| http://purl.uniprot.org/citations/12370366 | http://purl.uniprot.org/core/author | "Nakamura K."xsd:string |
| http://purl.uniprot.org/citations/12370366 | http://purl.uniprot.org/core/author | "Matsuoka S."xsd:string |
| http://purl.uniprot.org/citations/12370366 | http://purl.uniprot.org/core/author | "Fujii H."xsd:string |
| http://purl.uniprot.org/citations/12370366 | http://purl.uniprot.org/core/author | "Shimokawa T."xsd:string |
| http://purl.uniprot.org/citations/12370366 | http://purl.uniprot.org/core/author | "Zhang D."xsd:string |
| http://purl.uniprot.org/citations/12370366 | http://purl.uniprot.org/core/author | "Abe M."xsd:string |
| http://purl.uniprot.org/citations/12370366 | http://purl.uniprot.org/core/author | "Hirose S."xsd:string |
| http://purl.uniprot.org/citations/12370366 | http://purl.uniprot.org/core/author | "Ono M."xsd:string |
| http://purl.uniprot.org/citations/12370366 | http://purl.uniprot.org/core/author | "Shirai T."xsd:string |
| http://purl.uniprot.org/citations/12370366 | http://purl.uniprot.org/core/author | "Takai T."xsd:string |
| http://purl.uniprot.org/citations/12370366 | http://purl.uniprot.org/core/author | "Hamano Y."xsd:string |
| http://purl.uniprot.org/citations/12370366 | http://purl.uniprot.org/core/author | "Xiu Y."xsd:string |
| http://purl.uniprot.org/citations/12370366 | http://purl.uniprot.org/core/author | "Ra C."xsd:string |
| http://purl.uniprot.org/citations/12370366 | http://purl.uniprot.org/core/author | "Tsurui H."xsd:string |
| http://purl.uniprot.org/citations/12370366 | http://purl.uniprot.org/core/author | "Wen X.S."xsd:string |
| http://purl.uniprot.org/citations/12370366 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12370366 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/12370366 | http://purl.uniprot.org/core/pages | "4340-4346"xsd:string |
| http://purl.uniprot.org/citations/12370366 | http://purl.uniprot.org/core/title | "Transcriptional regulation of Fcgr2b gene by polymorphic promoter region and its contribution to humoral immune responses."xsd:string |
| http://purl.uniprot.org/citations/12370366 | http://purl.uniprot.org/core/volume | "169"xsd:string |