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| http://purl.uniprot.org/citations/12370393 | http://www.w3.org/2000/01/rdf-schema#comment | "We evaluated the effects of synthetic peptides (2017, 2019, 2020, 2021, 2023, 2027, 2029, 2030, 2031, and 2035) encompassing the structure of HIV-1(MN) envelope gp41 on both chemotaxis of human basophils and the release of preformed mediators (histamine) and of cytokines (IL-13). Peptides 2019 and 2021 were potent basophil chemoattractants, whereas the other peptides examined were ineffective. Preincubation of basophils with FMLP or gp41 2019 resulted in complete desensitization to a subsequent challenge with homologous stimulus. Incubation of basophils with low concentration (5 x 10(-7) M) of FMLP, which binds with high affinity to N-formyl peptide receptor (FPR), but not to FPR-like 1, did not affect the chemotactic response to a heterologous stimulus (gp41 2019). In contrast, a high concentration (10(-4) M) of FMLP, which binds also to FPR-like 1, significantly reduced the chemotactic response to gp41 2019. The FPR antagonist cyclosporin H inhibited chemotaxis induced by FMLP, but not by gp41 2019. None of these peptides singly induced the release of histamine or cytokines (IL-4 and IL-13) from basophils. However, low concentrations of peptides 2019 and 2021 (10(-8)-10(-6) M) inhibited histamine release from basophils challenged with FMLP but not the secretion caused by anti-IgE and gp120. Preincubation of basophils with peptides 2019 and 2021 inhibited the expression of both IL-13 mRNA, and the FMLP-induced release of IL-13 from basophils. These data highlight the complexity of the interactions between viral and bacterial peptides with FPR subtypes on human basophils."xsd:string |
| http://purl.uniprot.org/citations/12370393 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.169.8.4559"xsd:string |
| http://purl.uniprot.org/citations/12370393 | http://purl.uniprot.org/core/author | "Genovese A."xsd:string |
| http://purl.uniprot.org/citations/12370393 | http://purl.uniprot.org/core/author | "Marone G."xsd:string |
| http://purl.uniprot.org/citations/12370393 | http://purl.uniprot.org/core/author | "Triggiani M."xsd:string |
| http://purl.uniprot.org/citations/12370393 | http://purl.uniprot.org/core/author | "Fiorentino I."xsd:string |
| http://purl.uniprot.org/citations/12370393 | http://purl.uniprot.org/core/author | "Florio G."xsd:string |
| http://purl.uniprot.org/citations/12370393 | http://purl.uniprot.org/core/author | "Prevete N."xsd:string |
| http://purl.uniprot.org/citations/12370393 | http://purl.uniprot.org/core/author | "de Paulis A."xsd:string |
| http://purl.uniprot.org/citations/12370393 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12370393 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/12370393 | http://purl.uniprot.org/core/pages | "4559-4567"xsd:string |
| http://purl.uniprot.org/citations/12370393 | http://purl.uniprot.org/core/title | "HIV-1 envelope gp41 peptides promote migration of human Fc epsilon RI+ cells and inhibit IL-13 synthesis through interaction with formyl peptide receptors."xsd:string |
| http://purl.uniprot.org/citations/12370393 | http://purl.uniprot.org/core/volume | "169"xsd:string |
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