http://purl.uniprot.org/citations/12370410 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
http://purl.uniprot.org/citations/12370410 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
http://purl.uniprot.org/citations/12370410 | http://www.w3.org/2000/01/rdf-schema#comment | "In eukaryotic cells, RAD52 protein plays a central role in genetic recombination and DNA repair by (i) promoting the annealing of complementary single-stranded DNA and (ii) stimulation of the RAD51 recombinase. The single-strand annealing domain resides in the N-terminal region of the protein and is highly conserved, whereas the nonconserved RAD51-interaction domain is located in the C-terminal region. An N-terminal fragment of human RAD52 (residues 1-209) has been purified to homogeneity and, similar to the full-size protein (residues 1-418), shown to promote single-strand annealing in vitro. We have determined the crystal structure of this single-strand annealing domain at 2.7 A. The structure reveals an undecameric (11) subunit ring with extensive subunit contacts. A large, positively charged groove runs along the surface of the ring, readily suggesting a mechanism by which RAD52 presents the single strand for reannealing with complementary single-stranded DNA."xsd:string |
http://purl.uniprot.org/citations/12370410 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.212449899"xsd:string |
http://purl.uniprot.org/citations/12370410 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.212449899"xsd:string |
http://purl.uniprot.org/citations/12370410 | http://purl.uniprot.org/core/author | "Liu Y."xsd:string |
http://purl.uniprot.org/citations/12370410 | http://purl.uniprot.org/core/author | "Liu Y."xsd:string |
http://purl.uniprot.org/citations/12370410 | http://purl.uniprot.org/core/author | "Singleton M.R."xsd:string |
http://purl.uniprot.org/citations/12370410 | http://purl.uniprot.org/core/author | "Singleton M.R."xsd:string |
http://purl.uniprot.org/citations/12370410 | http://purl.uniprot.org/core/author | "Wigley D.B."xsd:string |
http://purl.uniprot.org/citations/12370410 | http://purl.uniprot.org/core/author | "Wigley D.B."xsd:string |
http://purl.uniprot.org/citations/12370410 | http://purl.uniprot.org/core/author | "West S.C."xsd:string |
http://purl.uniprot.org/citations/12370410 | http://purl.uniprot.org/core/author | "West S.C."xsd:string |
http://purl.uniprot.org/citations/12370410 | http://purl.uniprot.org/core/author | "Wentzell L.M."xsd:string |
http://purl.uniprot.org/citations/12370410 | http://purl.uniprot.org/core/author | "Wentzell L.M."xsd:string |
http://purl.uniprot.org/citations/12370410 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
http://purl.uniprot.org/citations/12370410 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
http://purl.uniprot.org/citations/12370410 | http://purl.uniprot.org/core/name | "Proc. Natl. Acad. Sci. U.S.A."xsd:string |
http://purl.uniprot.org/citations/12370410 | http://purl.uniprot.org/core/name | "Proc. Natl. Acad. Sci. U.S.A."xsd:string |
http://purl.uniprot.org/citations/12370410 | http://purl.uniprot.org/core/pages | "13492-13497"xsd:string |
http://purl.uniprot.org/citations/12370410 | http://purl.uniprot.org/core/pages | "13492-13497"xsd:string |
http://purl.uniprot.org/citations/12370410 | http://purl.uniprot.org/core/title | "Structure of the single-strand annealing domain of human RAD52 protein."xsd:string |
http://purl.uniprot.org/citations/12370410 | http://purl.uniprot.org/core/title | "Structure of the single-strand annealing domain of human RAD52 protein."xsd:string |
http://purl.uniprot.org/citations/12370410 | http://purl.uniprot.org/core/volume | "99"xsd:string |
http://purl.uniprot.org/citations/12370410 | http://purl.uniprot.org/core/volume | "99"xsd:string |