| http://purl.uniprot.org/citations/12370808 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12370808 | http://www.w3.org/2000/01/rdf-schema#comment | "Sam68 is a target of the c-Src tyrosine kinase. We previously showed that overexpression of Sam68 functionally substitutes for, as well as synergies with, HIV-1 Rev in Rev-response element (RRE)-mediated gene expression and virus replication. Here we describe the identification of heterogeneous nuclear ribonucleoprotein K (hnRNP K) as a protein that specifically interacts with Sam68 in vitro and in vivo. HnRNP K did not bind to RRE-RNA directly, but formed a super complex with Sam68 and RRE in vitro. RNase treatment did not change the strength of binding of hnRNP K to Sam68. We demonstrated that hnRNP K significantly inhibited Sam68-mediated, but not Rev-mediated, RRE-dependent gene expression. We further showed that Sam68, but not a non-functional mutant Sam68p21, inhibited transcriptional activation of CT element by hnRNP K. Interestingly, the Sam68p21 with a single amino acid substitution in the nuclear localization domain exhibited less affinity for hnRNP K in vitro. We propose that the direct interaction of Sam68 and hnRNP K adversely affect the activities of both proteins in signal transduction pathways of both transcriptional and post-transcriptional events."xsd:string |
| http://purl.uniprot.org/citations/12370808 | http://purl.org/dc/terms/identifier | "doi:10.1038/sj.onc.1205759"xsd:string |
| http://purl.uniprot.org/citations/12370808 | http://purl.uniprot.org/core/author | "Wong-Staal F."xsd:string |
| http://purl.uniprot.org/citations/12370808 | http://purl.uniprot.org/core/author | "Reddy T.R."xsd:string |
| http://purl.uniprot.org/citations/12370808 | http://purl.uniprot.org/core/author | "Yang J.P."xsd:string |
| http://purl.uniprot.org/citations/12370808 | http://purl.uniprot.org/core/author | "Suhasini M."xsd:string |
| http://purl.uniprot.org/citations/12370808 | http://purl.uniprot.org/core/author | "Truong K.T."xsd:string |
| http://purl.uniprot.org/citations/12370808 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12370808 | http://purl.uniprot.org/core/name | "Oncogene"xsd:string |
| http://purl.uniprot.org/citations/12370808 | http://purl.uniprot.org/core/pages | "7187-7194"xsd:string |
| http://purl.uniprot.org/citations/12370808 | http://purl.uniprot.org/core/title | "Functional interaction of Sam68 and heterogeneous nuclear ribonucleoprotein K."xsd:string |
| http://purl.uniprot.org/citations/12370808 | http://purl.uniprot.org/core/volume | "21"xsd:string |
| http://purl.uniprot.org/citations/12370808 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12370808 |
| http://purl.uniprot.org/citations/12370808 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/12370808 |
| http://purl.uniprot.org/uniprot/#_B4DFF1-mappedCitation-12370808 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12370808 |
| http://purl.uniprot.org/uniprot/#_B3KU16-mappedCitation-12370808 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12370808 |
| http://purl.uniprot.org/uniprot/#_B2R7B5-mappedCitation-12370808 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12370808 |
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| http://purl.uniprot.org/uniprot/#_Q07666-mappedCitation-12370808 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12370808 |
| http://purl.uniprot.org/uniprot/#_P61978-mappedCitation-12370808 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12370808 |
| http://purl.uniprot.org/uniprot/#_Q5EC54-mappedCitation-12370808 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12370808 |
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