| http://purl.uniprot.org/citations/12372335 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12372335 | http://www.w3.org/2000/01/rdf-schema#comment | "Mutational inactivation of the adenomatous polyposis coli (APC) protein initiates most hereditary and sporadic colon cancers. The tumor-suppressive effect of APC is mediated by promoting degradation of the oncogenic transcriptional activator beta-catenin, and loss of APC function often results in nuclear accumulation of beta-catenin in cancer cells. APC is a nuclear-cytoplasmic shuttling protein and moves along microtubules in the cytoplasm. However, the molecular motor proteins responsible for APC translocation and the implications of APC trafficking on beta-catenin turnover are unknown. Here we show that APC protein is associated with microtubules and is colocalized with kinesin heavy chain (KHC) and beta-catenin to clusters of puncta at the tip regions of cellular extensions in a conditionally immortalized mouse colon epithelial cell line, young adult mouse colon (YAMC, APC+/+). Inhibition of KHC expression using an antisense oligonucleotide disrupts peripheral translocation of APC and induces nucleocytoplasmic accumulation of beta-catenin. These data indicate that KHC-mediated APC translocation is tightly coordinated with beta-catenin turnover in the cell."xsd:string |
| http://purl.uniprot.org/citations/12372335 | http://purl.org/dc/terms/identifier | "doi:10.1006/excr.2002.5506"xsd:string |
| http://purl.uniprot.org/citations/12372335 | http://purl.uniprot.org/core/author | "Dong M."xsd:string |
| http://purl.uniprot.org/citations/12372335 | http://purl.uniprot.org/core/author | "Cui H."xsd:string |
| http://purl.uniprot.org/citations/12372335 | http://purl.uniprot.org/core/author | "Rosenberg D.W."xsd:string |
| http://purl.uniprot.org/citations/12372335 | http://purl.uniprot.org/core/author | "Sadhu D.N."xsd:string |
| http://purl.uniprot.org/citations/12372335 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12372335 | http://purl.uniprot.org/core/name | "Exp Cell Res"xsd:string |
| http://purl.uniprot.org/citations/12372335 | http://purl.uniprot.org/core/pages | "12-23"xsd:string |
| http://purl.uniprot.org/citations/12372335 | http://purl.uniprot.org/core/title | "Suppression of kinesin expression disrupts adenomatous polyposis coli (APC) localization and affects beta-catenin turnover in young adult mouse colon (YAMC) epithelial cells."xsd:string |
| http://purl.uniprot.org/citations/12372335 | http://purl.uniprot.org/core/volume | "280"xsd:string |
| http://purl.uniprot.org/citations/12372335 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12372335 |
| http://purl.uniprot.org/citations/12372335 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/12372335 |
| http://purl.uniprot.org/uniprot/#_D3Z7S6-mappedCitation-12372335 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12372335 |
| http://purl.uniprot.org/uniprot/#_E9QAK5-mappedCitation-12372335 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12372335 |
| http://purl.uniprot.org/uniprot/#_D3Z5Q1-mappedCitation-12372335 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12372335 |
| http://purl.uniprot.org/uniprot/#_E9Q6A9-mappedCitation-12372335 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12372335 |
| http://purl.uniprot.org/uniprot/#_F7CRC6-mappedCitation-12372335 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12372335 |
| http://purl.uniprot.org/uniprot/#_B2RUG9-mappedCitation-12372335 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12372335 |
| http://purl.uniprot.org/uniprot/#_E9QLQ9-mappedCitation-12372335 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12372335 |
| http://purl.uniprot.org/uniprot/#_F6Z405-mappedCitation-12372335 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12372335 |
| http://purl.uniprot.org/uniprot/#_D3YUH4-mappedCitation-12372335 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12372335 |
| http://purl.uniprot.org/uniprot/#_P70382-mappedCitation-12372335 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12372335 |
| http://purl.uniprot.org/uniprot/#_F7BAC9-mappedCitation-12372335 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12372335 |