| http://purl.uniprot.org/citations/12372336 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12372336 | http://www.w3.org/2000/01/rdf-schema#comment | "Interleukin-6 (IL-6) promotes osteodifferentiation in bone-located progenitors; however, it is not known whether this cytokine affects the differentiation of bone marrow-located osteoprogenitors. To address this issue, we prepared human bone marrow-derived mesenchymal stem cells (MSCs), which were characterized by a cell surface phenotype and multipotential nature. It was observed that in the presence of IL-6, MSCs were not differentiated into the osteogenic lineage, as evidenced by a failure to induce alkaline phosphatase activity, an earlier marker of osteodifferentiation. The lack of effect of IL-6 correlates with the observation that MSCs do not express a membrane-bound or soluble IL-6 receptor (sIL-6R). The incompetence of IL-6 was not reversed by the addition of sIL-6R alone or the sIL-6R/IL-6 complex, as it occurs in other IL-6R-negative cells. However, after MSC osteocommittment by dexamethasone, sIL-6R or the sIL-6R/IL-6 complex enhanced alkaline phosphatase activity. The effect of sIL-6R or sIL-6R/IL-6 proved to be dependent on gp130 availability, which is expressed by MSCs, and involves stat-3 phosphorylation. These data suggest that IL-6R deficiency may represent for bone marrow-located mesenchymal progenitors a sort of protective mechanism to escape the osteogenic effect of IL-6, which is produced by the MSC itself as well as by other marrow stromal cells."xsd:string |
| http://purl.uniprot.org/citations/12372336 | http://purl.org/dc/terms/identifier | "doi:10.1006/excr.2002.5627"xsd:string |
| http://purl.uniprot.org/citations/12372336 | http://purl.uniprot.org/core/author | "Rojas C."xsd:string |
| http://purl.uniprot.org/citations/12372336 | http://purl.uniprot.org/core/author | "Conget P."xsd:string |
| http://purl.uniprot.org/citations/12372336 | http://purl.uniprot.org/core/author | "Erices A."xsd:string |
| http://purl.uniprot.org/citations/12372336 | http://purl.uniprot.org/core/author | "Minguell J.J."xsd:string |
| http://purl.uniprot.org/citations/12372336 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12372336 | http://purl.uniprot.org/core/name | "Exp Cell Res"xsd:string |
| http://purl.uniprot.org/citations/12372336 | http://purl.uniprot.org/core/pages | "24-32"xsd:string |
| http://purl.uniprot.org/citations/12372336 | http://purl.uniprot.org/core/title | "Gp130 activation by soluble interleukin-6 receptor/interleukin-6 enhances osteoblastic differentiation of human bone marrow-derived mesenchymal stem cells."xsd:string |
| http://purl.uniprot.org/citations/12372336 | http://purl.uniprot.org/core/volume | "280"xsd:string |
| http://purl.uniprot.org/citations/12372336 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12372336 |
| http://purl.uniprot.org/citations/12372336 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/12372336 |
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