| http://purl.uniprot.org/citations/12372791 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12372791 | http://www.w3.org/2000/01/rdf-schema#comment | "Acute hypertension inhibits proximal tubule (PT) sodium reabsorption. The resultant increase in NaCl delivery to the macula densa suppresses renin release. We tested whether the sustained pressure-induced inhibition of PT sodium reabsorption requires a renin-mediated decrease in ANG II levels. Plasma ANG II concentration of anesthesized Sprague-Dawley rats was clamped by simultaneous infusion of the ANG I-converting enzyme inhibitor captopril (12 microg/min) and ANG II (20 ng. kg(-1). min(-1)). Blood pressure was increased 50 mmHg for 20 min by arterial constriction +/-ANG II clamp or by sham operation. This acute hypertension increased urine output and endogenous Li(+) clearance, and these responses were blunted 40-50% in ANG II clamped rats. Acute hypertension provoked a rapid redistribution of Na(+)/H(+) exchanger isoform 3 (NHE3) out of apical brush-border membranes (21 +/-4% decrease of total NHE3 abundance) to endosomal/lysosomal membranes (16 +/-6% increase of total). In ANG II-clamped rats, acute hypertension also provoked disappearance of NHE3 from the apical membranes (27 +/-2% decrease of total), but NHE3 was shifted to membranes enriched in intermicrovillar cleft and dense apical tubules (step 1) rather than endosomal/lysosomal membranes (step 2). This difference was independently confirmed by confocal analysis. In contrast, the pressure-induced redistribution of Na(+)-P(i) cotransporter type 2 was not altered by ANG II clamp. We conclude that the responses to acute hypertension, including diuresis and redistribution of PT NHE3 into intracellular membranes, require a responsive renin-angiotensin system and that the responses may be induced by the sustained increase in NaCl delivery to the macula densa during acute hypertension."xsd:string |
| http://purl.uniprot.org/citations/12372791 | http://purl.org/dc/terms/identifier | "doi:10.1152/ajprenal.00178.2002"xsd:string |
| http://purl.uniprot.org/citations/12372791 | http://purl.uniprot.org/core/author | "McDonough A.A."xsd:string |
| http://purl.uniprot.org/citations/12372791 | http://purl.uniprot.org/core/author | "Yang L.E."xsd:string |
| http://purl.uniprot.org/citations/12372791 | http://purl.uniprot.org/core/author | "Holstein-Rathlou N.H."xsd:string |
| http://purl.uniprot.org/citations/12372791 | http://purl.uniprot.org/core/author | "Leong P.K."xsd:string |
| http://purl.uniprot.org/citations/12372791 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12372791 | http://purl.uniprot.org/core/name | "Am J Physiol Renal Physiol"xsd:string |
| http://purl.uniprot.org/citations/12372791 | http://purl.uniprot.org/core/pages | "F1142-50"xsd:string |
| http://purl.uniprot.org/citations/12372791 | http://purl.uniprot.org/core/title | "Angiotensin II clamp prevents the second step in renal apical NHE3 internalization during acute hypertension."xsd:string |
| http://purl.uniprot.org/citations/12372791 | http://purl.uniprot.org/core/volume | "283"xsd:string |
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