| http://purl.uniprot.org/citations/12374808 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12374808 | http://www.w3.org/2000/01/rdf-schema#comment | "Production of cytokines is one of the major mechanisms employed by CD4(+) T cells to coordinate immune responses. Although the molecular mechanisms controlling T cell cytokine production have been extensively studied, the factors that endow T cells with their ability to produce unique sets of cytokines have not been fully characterized. Interferon regulatory factor (IRF)-4 is a lymphoid-restricted member of the interferon regulatory factor family of transcriptional regulators, whose deficiency leads to a profound impairment in the ability of mature CD4(+) T cells to produce cytokines. In these studies, we have investigated the mechanisms employed by IRF-4 to control cytokine synthesis. We demonstrate that stable expression of IRF-4 in Jurkat T cells not only leads to a strong enhancement in the synthesis of interleukin (IL)-2, but also enables these cells to start producing considerable amounts of IL-4, IL-10, and IL-13. Transient transfection assays indicate that IRF-4 can transactivate luciferase reporter constructs driven by either the human IL-2 or the human IL-4 promoter. A detailed analysis of the effects of IRF-4 on the IL-4 promoter reveals that IRF-4 binds to a site adjacent to a functionally important NFAT binding element and that IRF-4 cooperates with NFATc1. These studies thus support the notion that IRF-4 represents one of the lymphoid-specific components that control the ability of T lymphocytes to produce a distinctive array of cytokines."xsd:string |
| http://purl.uniprot.org/citations/12374808 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m205895200"xsd:string |
| http://purl.uniprot.org/citations/12374808 | http://purl.uniprot.org/core/author | "Jang S.Y."xsd:string |
| http://purl.uniprot.org/citations/12374808 | http://purl.uniprot.org/core/author | "Fanzo J.C."xsd:string |
| http://purl.uniprot.org/citations/12374808 | http://purl.uniprot.org/core/author | "Pernis A.B."xsd:string |
| http://purl.uniprot.org/citations/12374808 | http://purl.uniprot.org/core/author | "Hu C.M."xsd:string |
| http://purl.uniprot.org/citations/12374808 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12374808 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/12374808 | http://purl.uniprot.org/core/pages | "49238-49246"xsd:string |
| http://purl.uniprot.org/citations/12374808 | http://purl.uniprot.org/core/title | "Modulation of T cell cytokine production by interferon regulatory factor-4."xsd:string |
| http://purl.uniprot.org/citations/12374808 | http://purl.uniprot.org/core/volume | "277"xsd:string |
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