| http://purl.uniprot.org/citations/12374810 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12374810 | http://www.w3.org/2000/01/rdf-schema#comment | "Kinases of the Jak family (Jak1/2/3 and Tyk2) interact with the membrane proximal domain of different cytokine receptors and play a critical role in the activation of cytokine and growth factor signaling pathways. In this report we demonstrate that both the Box 1 and Box 2 motif collaborate in the association and activation of Jak1 by type I interferons. Mutational analysis of the beta chain of type I interferon receptor (IFNalphaRbetaL/IFNAR2) revealed that Box 1 plays a more significant role in activation than in the association with Jak1. On the contrary, the Box 2 motif contributes more to the association with Jak1 than to kinase activation. Additionally, the study of the Jak1 binding sites on the IL2 receptor beta (IL2Rbeta), IFNgammaRalpha/IFNGR1, and IL10Ralpha/IL10R1 chains suggests that cytokine receptors have two different kinds of interaction with Jak1. One form of interaction involves the Box 1 and the previously described Box 2 motif, which we now designate as Box 2A, characterized by the VEVI and LEVL sequences present in IFNalphaRbetaL/IFNAR2 and IL2Rbeta subunits, respectively. The second form of interaction requires a motif termed Box 2B, which is present in the IFNgammaRalpha/IFNGR1 (SILLPKS) and IL10Ralpha/IL10R1 (SVLLFKK) chains. Interestingly, Box 2B localizes close to the membrane region (8-10 amino acids from the membrane) similar to Box 1, whereas Box 2A is more distal (38-58 amino acids from the membrane)."xsd:string |
| http://purl.uniprot.org/citations/12374810 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m205757200"xsd:string |
| http://purl.uniprot.org/citations/12374810 | http://purl.uniprot.org/core/author | "Kotenko S.V."xsd:string |
| http://purl.uniprot.org/citations/12374810 | http://purl.uniprot.org/core/author | "Goldsmith M.A."xsd:string |
| http://purl.uniprot.org/citations/12374810 | http://purl.uniprot.org/core/author | "Nelms K."xsd:string |
| http://purl.uniprot.org/citations/12374810 | http://purl.uniprot.org/core/author | "Sandoval R."xsd:string |
| http://purl.uniprot.org/citations/12374810 | http://purl.uniprot.org/core/author | "Colamonici O.R."xsd:string |
| http://purl.uniprot.org/citations/12374810 | http://purl.uniprot.org/core/author | "Usacheva A."xsd:string |
| http://purl.uniprot.org/citations/12374810 | http://purl.uniprot.org/core/author | "Domanski P."xsd:string |
| http://purl.uniprot.org/citations/12374810 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12374810 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/12374810 | http://purl.uniprot.org/core/pages | "48220-48226"xsd:string |
| http://purl.uniprot.org/citations/12374810 | http://purl.uniprot.org/core/title | "Contribution of the Box 1 and Box 2 motifs of cytokine receptors to Jak1 association and activation."xsd:string |
| http://purl.uniprot.org/citations/12374810 | http://purl.uniprot.org/core/volume | "277"xsd:string |
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